Evidence map›Paper›PMID 26678632›Full record

SynthesisAmerican heart journal2015

Association between anxiety and mortality in patients with coronary artery disease: A meta-analysis.

Christopher M Celano, Rachel A Millstein, C Andres Bedoya, Brian C Healy, Annelieke M Roest, Jeff C Huffman

Registry-linked trialAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in American heart journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03057691 (The Impact of Depression and/or Anxiety on Patients With Acute Coronary Syndrome After Percutaneous Coronary Interventions), which is not on this map. Cited by 111 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03057691 unknown statusnot on this mapstarted 2017, after this paper: background citation

The Impact of Depression and/or Anxiety on Patients With Acute Coronary Syndrome After Percutaneous Coronary Interventions

TypeobservationalSponsorFirst Affiliated Hospital Xi'an Jiaotong UniversityRan2017 to 2020Enrolled5,000ConditionsAcute Coronary Syndrome, Depression, AnxietyArmsantidepressive and anti-anxiety therapy
3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Anxiety disorders and all-cause mortality: systematic review and meta-analysis.Social psychiatry and psychiatric epidemiology · 2016
    Pooled it
  8. Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christopher M CelanoDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address: ccelano@partners.org.
Rachel A MillsteinDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.
C Andres BedoyaDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.
Brian C HealyHarvard Medical School, Boston, MA; Department of Neurology, Massachusetts General Hospital, Boston, MA.
Annelieke M RoestInterdisciplinary Center Psychopathology and Emotion Regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jeff C HuffmanDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA; Department of Neurology, Massachusetts General Hospital, Boston, MA.

Funding

Developing a positive psychology intervention to improve cardiac health behaviorsR01HL113272 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HUFFMAN, JEFF C · 2013 to 2017
$2.6M
A positive psychology intervention to promote health behaviors in heart failureK23HL123607 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI CELANO, CHRISTOPHER M · 2015 to 2019
$859k
NHLBI NIH HHS K23 HL123607NHLBI NIH HHS R01 HL113272
6 · The paper itself

Abstract

backgroundDepression and anxiety are common in patients with coronary artery disease (CAD). Although depression clearly has been associated with mortality in this population, the relationship between anxiety and mortality is less clear. Accordingly, we performed a series of meta-analyses to (1) examine the relationship between anxiety and mortality in patients with established CAD and (2) determine if this relationship differs in patients with stable CAD compared to those who have just had an acute coronary syndrome (ACS). METHODS AND

resultsSystematic literature searches identified 44 articles (total N = 30,527) evaluating the prospective relationship between anxiety and mortality in individuals with established CAD. A series of 8 adjusted and unadjusted meta-analyses were performed to examine this relationship across all patients, with sensitivity analyses completed in post-ACS and stable CAD cohorts. In unadjusted analyses, anxiety was associated with a moderate increase in mortality risk (odds ratio 1.21 per SD increase in anxiety). However, when adjusting for covariates, nearly all associations became nonsignificant. In sensitivity analyses, anxiety was associated with an increased risk of poor outcomes in the stable CAD-but not post-ACS-cohort.

conclusionsThese analyses confirm that anxiety is associated with increased risk of mortality in patients with CAD; however, this relationship is not as strong as that of depression and may be explained partly by other clinical factors. If anxiety screening is performed, it should be performed during a period of clinical stability and should target anxiety disorders rather than anxiety symptoms alone.

Indexed as

AnxietyCoronary Artery DiseaseCoronary AngiographyHumansRisk AssessmentRisk FactorsSurvival Analysis

Identifiers

PMID26678632
PMCPMC4684590

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.