ArticleScientific reports2015
Wireless fluorescence capsule for endoscopy using single photon-based detection.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Wireless, Deep-Seeing Smart Pill: A NIR-II Fluorescence Imaging Capsule Endoscope for Gastrointestinal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A NIR-IIb-excited capsule endoscope enabling high-contrast fluorescence imaging via spectrally-isolated detection for early-stage gastrointestinal cancer.Journal of nanobiotechnology · 2026Article
- High crosstalk suppression in InGaAs/InP single-photon avalanche diode arrays by carrier extraction structure.Nature communications · 2024Article
- A swallowable X-ray dosimeter for the real-time monitoring of radiotherapy.Nature biomedical engineering · 2023Article
- Capsule Endoscopy: Pitfalls and Approaches to Overcome.Diagnostics (Basel, Switzerland) · 2021Review
- Examination of Entire Gastrointestinal Tract: A Perspective of Mouth to Anus (M2A) Capsule Endoscopy.Diagnostics (Basel, Switzerland) · 2021Review
- Review
- Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall.Scientific reports · 2021Article
- Gastrointestinal diagnosis using non-white light imaging capsule endoscopy.Nature reviews. Gastroenterology & hepatology · 2019Review
- Nano-plasmonics and electronics co-integration in CMOS enabling a pill-sized multiplexed fluorescence microarray system.Biomedical optics express · 2018Article
- Silicon single-photon avalanche diodes with nano-structured light trapping.Nature communications · 2017Article
- Acoustic Sensing and Ultrasonic Drug Delivery in Multimodal Theranostic Capsule Endoscopy.Sensors (Basel, Switzerland) · 2017Article
- Ultrasound capsule endoscopy: sounding out the future.Annals of translational medicine · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescence Imaging (FI) is a powerful technique in biological science and clinical medicine. Current FI devices that are used either for in-vivo or in-vitro studies are expensive, bulky and consume substantial power, confining the technique to laboratories and hospital examination rooms. Here we present a miniaturised wireless fluorescence endoscope capsule with low power consumption that will pave the way for future FI systems and applications. With enhanced sensitivity compared to existing technology we have demonstrated that the capsule can be successfully used to image tissue autofluorescence and targeted fluorescence via fluorophore labelling of tissues. The capsule incorporates a state-of-the-art complementary metal oxide semiconductor single photon avalanche detector imaging array, miniaturised optical isolation, wireless technology and low power design. When in use the capsule consumes only 30.9 mW, and deploys very low-level 468 nm illumination. The device has the potential to replace highly power-hungry intrusive optical fibre based endoscopes and to extend the range of clinical examination below the duodenum. To demonstrate the performance of our capsule, we imaged fluorescence phantoms incorporating principal tissue fluorophores (flavins) and absorbers (haemoglobin). We also demonstrated the utility of marker identification by imaging a 20 μM fluorescein isothiocyanate (FITC) labelling solution on mammalian tissue.
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Registered trials
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