Evidence map›Paper›PMID 26678242›Full record

ArticleStatistics in medicine2016

Propensity score and doubly robust methods for estimating the effect of treatment on censored cost.

Jiaqi Li, Elizabeth Handorf, Justin Bekelman, Nandita Mitra

Open access · bronzeAbstract read
In one paragraph

Article in Statistics in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jiaqi LiDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, 19104, U.S.A.
Elizabeth HandorfBiostatistics and Bioinformatics Facility, Temple University Health System Fox Chase Cancer Center, Philadelphia, PA, 19111, U.S.A.
Justin BekelmanDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, U.S.A.
Nandita MitraDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, 19104, U.S.A.
University of Pennsylvania · USTemple University Health System · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8M
Effectiveness of Radiotherapy for Prostate CancerK07CA163616 · NCI · UNIVERSITY OF PENNSYLVANIA · PI BEKELMAN, JUSTIN · 2012 to 2016
$875k
NCI NIH HHS K07 CA163616NCI NIH HHS P30 CA006927
6 · The paper itself

Abstract

The estimation of treatment effects on medical costs is complicated by the need to account for informative censoring, skewness, and the effects of confounders. Because medical costs are often collected from observational claims data, we investigate propensity score (PS) methods such as covariate adjustment, stratification, and inverse probability weighting taking into account informative censoring of the cost outcome. We compare these more commonly used methods with doubly robust (DR) estimation. We then use a machine learning approach called super learner (SL) to choose among conventional cost models to estimate regression parameters in the DR approach and to choose among various model specifications for PS estimation. Our simulation studies show that when the PS model is correctly specified, weighting and DR perform well. When the PS model is misspecified, the combined approach of DR with SL can still provide unbiased estimates. SL is especially useful when the underlying cost distribution comes from a mixture of different distributions or when the true PS model is unknown. We apply these approaches to a cost analysis of two bladder cancer treatments, cystectomy versus bladder preservation therapy, using SEER-Medicare data. Copyright © 2015 John Wiley & Sons, Ltd.

Indexed as

Propensity ScoreTreatment OutcomeCost-Benefit AnalysisData Interpretation, StatisticalHealth Care CostsHumansMachine LearningModels, StatisticalProbabilitycost estimationdoubly robust estimationobservational studiespropensity scoressuper learner

Identifiers

PMID26678242
PMCPMC4848146
OpenAlexW2222353330

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.