Evidence map›Paper›PMID 26677969›Full record

ArticleLeukemia2016

New drug approvals in acute myeloid leukemia: what's the best end point?

E Estey, M Othus, S J Lee, F R Appelbaum, R P Gale

Abstract readEditorial
In one paragraph

Article in Leukemia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Age at Diagnosis and Patient Preferences for Treatment Outcomes in AML: A Discrete Choice Experiment to Explore Meaningful Benefits.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
  7. Article
  8. Review
  9. Single-agent and combination biologics in acute myeloid leukemia.Hematology. American Society of Hematology. Education Program · 2019
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Leukemic stem cells: identification and clinical application.International journal of hematology · 2017
    Review
  16. Review
  17. Article
  18. Acute Myeloid Leukemia: How Do We Measure Success?Current hematologic malignancy reports · 2016
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

E EsteyClinical Research Division and Division of Hematology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.
M OthusPublic Health Sciences Division's Biostatistics and Biomathematics Group, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.
S J LeeClinical Research Division and Division of Medical Oncology, University of Washington, Seattle, WA, USA.
F R AppelbaumClinical Research Division and Division of Medical Oncology, University of Washington, Seattle, WA, USA.
R P GaleDivision of Experimental Medicine, Department of Medicine, Haematology Research Centre, Imperial College London, London, UK.

Funding

Prediction of Treatment-Related Mortality and Therapeutic Resistance in AMLR21CA182010 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI OTHUS, MEGAN, WALTER, ROLAND BRUNO · 2014 to 2015
$430k
Department of HealthNCI NIH HHS CA182010NCI NIH HHS R21 CA182010
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Bone Marrow TransplantationBiomarkers, PharmacologicalDrug ApprovalDrugs, InvestigationalFusion Proteins, bcr-ablGene ExpressionHumansLeukemia, Myeloid, AcuteNeoplasm, ResidualPrognosisQuality of LifeRemission InductionSurvival AnalysisUnited StatesBCR-ABL1 fusion protein, humanBiomarkers, PharmacologicalDrugs, InvestigationalFusion Proteins, bcr-abl

Identifiers

PMID26677969
PMCPMC4777773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.