ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Social Isolation During Postweaning Development Causes Hypoactivity of Neurons in the Medial Nucleus of the Male Rat Amygdala.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 27 citations in OpenAlex.
- Adolescent isolation disrupts medial amygdala and ventral tegmental area maturation and sex-specifically dysregulates transcriptional responses to cocaine and stress.Neuropharmacology · 2025Article
- Repeated social stress increases posterior medial amygdala neuronal activity in stress-susceptible adult male rats.Journal of neurophysiology · 2025Article
- Developmental Shifts in Amygdala Function.Current topics in behavioral neurosciences · 2025Review
- Systemic histone deacetylase inhibition ameliorates the aberrant responses to acute stress in socially isolated male mice.The Journal of physiology · 2024Article
- Morphological changes in the basolateral amygdala and behavioral disruptions associated with social isolation.Behavioural brain research · 2022Article
- Affective Neuroscience of Loneliness: Potential Mechanisms underlying the Association between Perceived Social Isolation, Health, and Well-Being.Journal of psychiatry and brain science · 2022Article
- Maturation of amygdala inputs regulate shifts in social and fear behaviors: A substrate for developmental effects of stress.Neuroscience and biobehavioral reviews · 2021Review
- Article
- Translating Developmental Neuroscience to Understand Risk for Psychiatric Disorders.The American journal of psychiatry · 2019Review
- Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females.Frontiers in behavioral neuroscience · 2019Article
- Childhood stress, grown-up brain networks: corticolimbic correlates of threat-related early life stress and adult stress response.Psychological medicine · 2018Article
- An intra-amygdala circuit specifically regulates social fear learning.Nature neuroscience · 2017Article
- Consequences of early adverse rearing experience(EARE) on development: insights from non-human primate studies.Zoological research · 2017Review
- Emergence of social behavior deficit, blunted corticolimbic activity and adult depression-like behavior in a rodent model of maternal maltreatment.Translational psychiatry · 2016Article
- Differential influence of social versus isolate housing on vicarious fear learning in adolescent mice.Behavioral neuroscience · 2016Article
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2 authors at 1 institution in 1 country.
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Abstract
Children exposed to neglect or social deprivation are at heightened risk for psychiatric disorders and abnormal social patterns as adults. There is also evidence that prepubertal neglect in children causes abnormal metabolic activity in several brain regions, including the amygdala area. The medial nucleus of the amygdala (MeA) is a key region for performance of social behaviors and still undergoes maturation during the periadolescent period. As such, the normal development of this region may be disrupted by social deprivation. In rodents, postweaning social isolation causes a range of deficits in sexual and agonistic behaviors that normally rely on the posterior MeA (MeAp). However, little is known about the effects of social isolation on the function of MeA neurons. In this study, we tested whether postweaning social isolation caused abnormal activity of MeA neurons. We found that postweaning social isolation caused a decrease of in vivo firing activity of MeAp neurons, and reduced drive from excitatory afferents. In vitro electrophysiological studies found that postweaning social isolation caused a presynaptic impairment of excitatory input to the dorsal MeAp, but a progressive postsynaptic reduction of membrane excitability in the ventral MeAp. These results demonstrate discrete, subnucleus-specific effects of social deprivation on the physiology of MeAp neurons. This pathophysiology may contribute to the disruption of social behavior after developmental social deprivation, and may be a novel target to facilitate the treatment of social disorders.
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