ArticleThe European respiratory journal2016
Incidence of airflow limitation in subjects 65-100 years of age.
Article in The European respiratory journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Pulmonary function and airflow limitation in bronchiectasis: a case-control study of two independent cohorts.BMJ open respiratory research · 2026Article
- A single-cell atlas of lung homeostasis reveals dynamic changes during development and aging.Communications biology · 2024Article
- Is the GOLD guideline for diagnosing obstruction in COPD discriminatory in predicting severe future COPD-related exacerbations and death?Breathe (Sheffield, England) · 2021Article
- Association between cardiovascular disease- and inflammation-related serum biomarkers and poor lung function in elderly.Clinical proteomics · 2021Article
- Prevalence and characteristics of chronic obstructive pulmonary disease in China with a diagnostic criterion of FEVJournal of thoracic disease · 2021Article
- Pulmonary function parameters among marble industry workers in Lahore, Pakistan.F1000Research · 2021Article
- Fixed Ratio versus Lower Limit of Normality for Diagnosing COPD in Primary Care: Long-Term Follow-Up of EGARPOC Study.International journal of chronic obstructive pulmonary disease · 2020Article
- Animal Models Reflecting Chronic Obstructive Pulmonary Disease and Related Respiratory Disorders: Translating Pre-Clinical Data into Clinical Relevance.Journal of innate immunity · 2020Review
- COPD overdiagnosis in primary care: a UK observational study of consistency of airflow obstruction.NPJ primary care respiratory medicine · 2019Observational
- Relative and absolute lung function change in a general population aged 60-102 years.The European respiratory journal · 2019Article
- Prognostic Significance of Large Airway Dimensions on Computed Tomography in the General Population. The Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study.Annals of the American Thoracic Society · 2018Article
- Aging-related trajectories of lung function in the general population-The Doetinchem Cohort Study.PloS one · 2018Article
- Aging Airways: between Normal and Disease. A Multidimensional Diagnostic Approach by Combining Clinical, Functional, and Imaging Data.Aging and disease · 2017Review
- The short term burden of ambient fine particulate matter on chronic obstructive pulmonary disease in Ningbo, China.Environmental health : a global access science source · 2017Article
- An Official American Thoracic Society Workshop Report: Evaluation and Management of Asthma in the Elderly.Annals of the American Thoracic Society · 2016Article
- Airflow obstruction, atherosclerosis and cardiovascular risk factors in the AGES Reykjavik study.Atherosclerosis · 2016Article
- Asthma Over the Age of 65: All's Well That Ends Well.The journal of allergy and clinical immunology. In practiceReview
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The true incidence of chronic obstructive pulmonary disease is largely unknown, because the few longitudinal studies performed have used diagnostic criteria no longer recommended by either the European Respiratory Society or the American Thoracic Society (ATS).We studied the incidence and significance of airflow limitation in a population-based geriatric sample using both an age-dependent predicted lower limit of normal (LLN) value and a fixed-ratio spirometric criterion.Out of 2025 subjects with acceptable spirometry at baseline, 984 subjects aged 65-100 years completed a 6-year follow-up visit. Smoking habits were registered at baseline. Exclusion criteria were non-acceptable spirometry performance according to ATS criteria and inability to communicate. Airflow limitation was defined both according to forced expiratory volume in 1 s (FEV1)/forced vital capacity ratio <0.7 and <LLN.The incidence of airflow limitation per 1000 person-years was 28.2 using a fixed ratio and 11.7 with LLN, corresponding to a 1.41-fold higher incidence rate using a fixed ratio. The incidence increased dramatically with age when using a fixed ratio, but less so when using LLN. In addition, a sex effect was observed with the LLN criterion. LLN airflow limitation was associated with increased 5-year mortality. Presence of fixed-ratio airflow limitation in individuals classified by LLN as non-obstructive was not associated with increased mortality.
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