ArticleScientific reports2015
Characterization and Comparative Analysis of the Milk Transcriptome in Two Dairy Sheep Breeds using RNA Sequencing.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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44 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Weighted gene co-expression network analysis identifies modules and functionally enriched pathways in the lactation process.Scientific reports · 2021Pooled it
- Integrated methylome-transcriptome profiling reveals epigenetic regulation of immune activation pathways and CSN3-associated lactation repression in bovine subclinical mastitis.Journal of animal science and biotechnology · 2026Article
- Transcriptomic profiling of milk fat globules in cows with different β-casein genotypes.Scientific reports · 2025Article
- Comparative analysis of κ-casein expressions and dairy herd improvement indices in Chinese Holstein cows of diverse κ-casein genotypes and transcripts.Veterinary and animal science · 2025Article
- Preservation of milk in liquid nitrogen during sample collection does not affect the RNA quality for RNA-seq analysis.BMC genomics · 2025Article
- Selective sweep and mammary transcriptomics identify breed-specific lactation drivers in East Friesian dairy sheep.Journal of animal science · 2025Article
- Polymorphism of theAnimals : an open access journal from MDPI · 2024Article
- Transcriptome analysis of mammary epithelial cell between Sewa sheep and East FriEsian sheep from different localities.BMC genomics · 2024Article
- Genome-Wide Association Study of Conformation Traits in Brazilian Holstein Cattle.Animals : an open access journal from MDPI · 2024Article
- Using expression data to fine map QTL associated with fertility in dairy cattle.Genetics, selection, evolution : GSE · 2024Article
- Genome-Wide Signal Selection Analysis Revealing Genes Potentially Related to Sheep-Milk-Production Traits.Animals : an open access journal from MDPI · 2023Article
- High-density SNP markers elucidate the genetic divergence and population structure of Noticiana sheep breed in the Mediterranean context.Frontiers in veterinary science · 2023Article
- Intra- and Interspecies RNA-Seq Based Variants in the Lactation Process of Ruminants.Animals : an open access journal from MDPI · 2022Article
- Detection of candidate genes affecting milk production traits in sheep using whole-genome sequencing analysis.Veterinary medicine and science · 2022Article
- Whole-genome resequencing reveals genetic diversity and selection characteristics of dairy goat.Frontiers in genetics · 2022Article
- Characterization and comparative analysis of transcriptional profiles of porcine colostrum and mature milk at different parities.BMC genomic data · 2021Article
- Article
- Comparative Transcriptome Analysis of Milk Somatic Cells During Lactation Between Two Intensively Reared Dairy Sheep Breeds.Frontiers in genetics · 2021Article
- Effects of dietary polyunsaturated fatty acid sources on expression of lipid-related genes in bovine milk somatic cells.Scientific reports · 2020Article
- Analysis of Whole Genome Resequencing Datasets from a Worldwide Sample of Sheep Breeds to Identify Potential Causal Mutations Influencing Milk Composition Traits.Animals : an open access journal from MDPI · 2020Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
This study presents a dynamic characterization of the sheep milk transcriptome aiming at achieving a better understanding of the sheep lactating mammary gland. Transcriptome sequencing (RNA-seq) was performed on total RNA extracted from milk somatic cells from ewes on days 10, 50, 120 and 150 after lambing. The experiment was performed in Spanish Churra and Assaf breeds, which differ in their milk production traits. Nearly 67% of the annotated genes in the reference genome (Oar_v3.1) were expressed in ovine milk somatic cells. For the two breeds and across the four lactation stages studied, the most highly expressed genes encoded caseins and whey proteins. We detected 573 differentially expressed genes (DEGs) across lactation points, with the largest differences being found, between day 10 and day 150. Upregulated GO terms at late lactation stages were linked mainly to developmental processes linked to extracellular matrix remodeling. A total of 256 annotated DEGs were detected in the Assaf and Churra comparison. Some genes selectively upregulated in the Churra breed grouped under the endopeptidase and channel activity GO terms. These genes could be related to the higher cheese yield of this breed. Overall, this study provides the first integrated overview on sheep milk gene expression.
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