Evidence map›Paper›PMID 26677750›Full record

ArticleScientific reports2015

Principles of using Cold Atmospheric Plasma Stimulated Media for Cancer Treatment.

Dayun Yan, Annie Talbot, Niki Nourmohammadi, Xiaoqian Cheng, Jerome Canady, Jonathan Sherman, Michael Keidar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  20. Cellular Mechanisms of Singlet Oxygen in Photodynamic Therapy.International journal of molecular sciences · 2023
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dayun YanDepartment of Mechanical and Aerospace Engineering, The George Washington University, Science &Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052, USA.
Annie TalbotColumbian College of Arts and Sciences, The George Washington University, Phillips Hall, 801 22nd Street, NW, Suite 212, Washington, DC 20052, USA.
Niki NourmohammadiDepartment of Biological Sciences, The George Washington University, Lisner Hall, 2023 G Street, NW, Suite 340, Washington, DC 20052, USA.
Xiaoqian ChengDepartment of Mechanical and Aerospace Engineering, The George Washington University, Science &Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052, USA.
Jerome CanadyJerome Canady Research Institute for Advanced Biological and Technological Sciences, 6930 Carroll Avenue, 3rd floor Suite 300 Takoma Park, Maryland 20912, USA.
Jonathan ShermanNeurological Surgery, The George Washington University, Foggy Bottom South Pavilion, 22nd Street, NW, 7th Floor, Washington, DC 20037, USA.
Michael KeidarDepartment of Mechanical and Aerospace Engineering, The George Washington University, Science &Engineering Hall, 800 22nd Street, NW, Room 3550, Washington, DC 20052, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, the significant anti-cancer capacity of cold atmospheric plasma (CAP) on dozens of cancer cell lines has been demonstrated in vitro and in mice models. Conventionally, CAP was directly applied to irradiate cancer cells or tumor tissue. Over past three years, the CAP irradiated media was also found to kill cancer cells as effectively as the direct CAP treatment. As a novel strategy, using the CAP stimulated (CAPs) media has become a promising anti-cancer tool. In this study, we demonstrated several principles to optimize the anti-cancer capacity of the CAPs media on glioblastoma cells and breast cancer cells. Specifically, using larger wells on a multi-well plate, smaller gaps between the plasma source and the media, and smaller media volume enabled us to obtain a stronger anti-cancer CAPs media composition without increasing the treatment time. Furthermore, cysteine was the main target of effective reactive species in the CAPs media. Glioblastoma cells were more resistant to the CAPs media than breast cancer cells. Glioblastoma cells consumed the effective reactive species faster than breast cancer cells did. In contrast to nitric oxide, hydrogen peroxide was more likely to be the effective reactive species.

Indexed as

ApoptosisCell Line, TumorCold TemperatureCysteineHumansHydrogen PeroxideMCF-7 CellsNitric OxidePlasma GasesReactive Nitrogen SpeciesReactive Oxygen SpeciesTryptophanCysteineHydrogen PeroxideNitric OxidePlasma GasesReactive Nitrogen SpeciesReactive Oxygen SpeciesTryptophan

Identifiers

PMID26677750
PMCPMC4683589

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.