Trial reportThe Journal of bone and joint surgery. American volume2015
Effect of Naproxen Prophylaxis on Heterotopic Ossification Following Hip Arthroscopy: A Double-Blind Randomized Placebo-Controlled Trial.
Trial report in The Journal of bone and joint surgery. American volume, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- A systematic review and meta-analysis of naproxen for prevention heterotopic ossification after hip surgery.Medicine · 2019Pooled it
- The Effect of Non-Steroidal Anti-Inflammatory Drugs on Tendon-to-Bone Healing: A Systematic Review with Subgroup Meta-Analysis.The Iowa orthopaedic journal · 2019Pooled it
- Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis.Journal of orthopaedic surgery and research · 2018Pooled it
- Denosumab and bone loss in uncemented total hip arthroplasty: a secondary 5-year follow-up of a randomized controlled trial.Acta orthopaedica · 2026Trial
- The statistical fragility of randomized controlled trials comparing hip arthroscopy to conservative management for the treatment of femoroacetabular impingement syndrome.Journal of hip preservation surgery · 2026Review
- Chemoprophylaxis for Heterotopic Ossification After Hip Arthroscopy: A Systematic Review and Meta-analysis.Orthopaedic journal of sports medicine · 2026Review
- Opioid Usage, Disposal Methods, and NSAID Usage After Hip Arthroscopy.Orthopaedic journal of sports medicine · 2025Article
- Incidence of Heterotopic Ossification Without Additional Long-Term NSAID Prophylaxis After Periacetabular Osteotomy and Concomitant Hip Arthroscopy.Orthopaedic journal of sports medicine · 2025Article
- Identifying Hip Arthroscopy Trends in Turkey.Orthopaedic journal of sports medicine · 2024Article
- Emphasizing the Importance of Naproxen Prophylaxis May Decrease the Rate of Heterotopic Ossification After Hip Arthroscopy.Arthroscopy, sports medicine, and rehabilitation · 2024Article
- Demographic and Socioeconomic Patient Data Are Rarely Included in Randomized Controlled Trials for Femoral Acetabular Impingement and Hip Arthroscopy: A Systematic Review.Arthroscopy, sports medicine, and rehabilitation · 2024Review
- Immunologic Aspects in Fibrodysplasia Ossificans Progressiva.Biomolecules · 2024Review
- Role of the NF-kB signalling pathway in heterotopic ossification: biological and therapeutic significance.Cell communication and signaling : CCS · 2024Review
- Heterotopic Ossification in Hip Arthroscopy.Surgery journal (New York, N.Y.) · 2023Article
- Puncture Capsulotomy Technique for Hip Arthroscopy: Midterm Functional Outcomes.Orthopaedic journal of sports medicine · 2023Article
- Low-dose prophylaxis protocol for heterotopic ossification after hip preservation surgery in a sport participants cohort.SICOT-J · 2023Article
- Identification of Risk Factors in the Development of Heterotopic Ossification After Primary Total Hip Arthroplasty.The Journal of clinical endocrinology and metabolism · 2022Article
- Heterotopic Ossification After Arthroscopic Procedures: A Scoping Review of the Literature.Orthopaedic journal of sports medicine · 2022Article
- Hip Capsular Deficiency-A Cause of Post-Surgical Instability in the Revision Setting Following Hip Arthroscopy for Femoroacetabular Impingement.Current reviews in musculoskeletal medicine · 2021Review
- Incidence of Heterotopic Ossification with NSAID Prophylaxis Is Low After Open and Arthroscopic Hip Preservation Surgery.Arthroscopy, sports medicine, and rehabilitation · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHeterotopic ossification (HO) is a known complication of hip arthroscopy. Our objective was to determine the effect of postoperative naproxen therapy on the development of HO following arthroscopic surgery for femoroacetabular impingement.
methodsBetween August 2011 and April 2013, 108 eligible patients were enrolled and randomized to take naproxen or a placebo for three weeks postoperatively. Radiographs were made at routine follow-up visits for one year following surgery. The primary outcome measure was the development of HO, as classified with the Brooker criteria and two-dimensional measurements on radiographs made at least seventy-five days postoperatively (average, 322 days). The primary analysis, performed with a Fisher exact test, compared the proportion of subjects with HO between the treatment and control groups. A single a priori interim analysis was planned at the midpoint of the study.
resultsOur data safety and monitoring board stopped this study when the interim analysis showed that the stopping criterion had been met for demonstration of efficacy of the naproxen intervention. The prevalence of HO was 46% (twenty-two of the forty-eight in the final analysis) in the placebo group versus 4% (two of forty-eight) in the naproxen group (p < 0.001). Medication compliance was 69% overall, but it did not differ between the naproxen and placebo groups. Minor adverse reactions to the study medications were reported in 42% of the patients taking naproxen versus 35% of those taking the placebo (p = 0.45).
conclusionsIn this trial, prophylaxis with naproxen was effective in reducing the prevalence of HO without medication-related morbidity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.