Evidence map›Paper›PMID 26677196›Full record

ReviewCurrent neurology and neuroscience reports2016

Infection and Stroke: an Update on Recent Progress.

Eliza C Miller, Mitchell S V Elkind

Abstract readReview
In one paragraph

Review in Current neurology and neuroscience reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Stroke Care in Conflict and War Zones -Peace Saves Lives!Current neurology and neuroscience reports · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Neurological complications and infection mechanism of SARS-COV-2.Signal transduction and targeted therapy · 2021
    Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Eliza C MillerThe Neurological Institute of New York, 710 W. 168th St., 14th floor, New York, NY, 10032, USA. ecm2137@cumc.columbia.edu.
Mitchell S V ElkindThe Neurological Institute of New York, 710W. 168th St., Room 642, New York, NY, 10032, USA. mse13@cumc.columbia.edu.
The Neurological Institute · US

Funding

New York Stroke Trials Network of Columbia and Cornell (NYCCSTN)U10NS086728 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARSHALL, RANDOLPH S · 2013 to 2017
$2.0M
NINDS NIH HHS U10 NS086728
6 · The paper itself

Abstract

The role of infection in cerebrovascular disease is complex and remains incompletely understood. Over the last 5 years, investigators have made notable inroads in untangling this thorny topic. In this review, we examine these recent developments, concentrating on four aspects of the relationship between infection and stroke. We first discuss specific infectious agents as direct causes of stroke, focusing on recent work implicating herpesviruses and HIV in cerebral vasculopathy. We then discuss systemic infection of any type as a stroke trigger, focusing on the relationship of infection to timing of acute stroke, both in children and adults, as well as the role of vaccination in stroke prevention. We examine the evidence for chronic infection or "infectious burden" as a stroke risk factor. Finally, we discuss recent work on infection as a risk factor for increased morbidity after stroke, possible mechanisms mediating this effect, and the evidence for prophylactic antibiotics.

Indexed as

AnimalsHerpesviridae InfectionsHIV InfectionsHumansRisk FactorsStrokeVaccinationHerpesvirusHIVInfectionInfectious burdenStrokeVaccination

Identifiers

PMID26677196
PMCPMC6440211
OpenAlexW2239639211

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.