ArticleAngewandte Chemie (International ed. in English)2016
Asymmetric Synthesis of Spiropyrazolones by Sequential Organo- and Silver Catalysis.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 124 citations in OpenAlex.
- Enantioselective Synthesis of 3-Alkyl-1,5-Functionalized 1,4-Diynes via Isoxazol-5(4Organic letters · 2026Article
- Photoenzymatic catalysis enables enantioselective radical dearomative spirocyclization.Nature communications · 2025Article
- Enantioselective Synthesis of Spirocyclic Isoxazolones Using a Conia-Ene Type Reaction.The Journal of organic chemistry · 2025Article
- Synthesis of fully functionalised spiropyran pyrazolone skeletonsRSC advances · 2022Article
- Experimental and Theoretical DFT Investigations in the [2,3]-Wittig-Type Rearrangement of Propargyl/Allyl-Oxy-Pyrazolones.Molecules (Basel, Switzerland) · 2021Article
- Single-atom Fe catalytic amplification-gold nanosol SERS/RRS aptamer as platform for the quantification of trace pollutants.Mikrochimica acta · 2021Article
- Stretchable chiral pockets for palladium-catalyzed highly chemo- and enantioselective allenylation.Nature communications · 2021Article
- Combined inorganic base promoted N-addition/[2,3]-sigmatropic rearrangement to construct homoallyl sulfur-containing pyrazolones.RSC advances · 2019Article
- Proline bulky substituents consecutively act as steric hindrances and directing groups in a Michael/Conia-ene cascade reaction under synergistic catalysis.Chemical science · 2019Article
- Enantioselective Tandem Cyclization of Alkyne-Tethered Indoles Using Cooperative Silver(I)/Chiral Phosphoric Acid Catalysis.Angewandte Chemie (International ed. in English) · 2017Article
- One-pot synthesis of (-)-Ambrox.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
A stereoselective one-pot synthesis of spiropyrazolones through an organocatalytic asymmetric Michael addition and a formal Conia-ene reaction has been developed. Depending on the nitroalkene, the 5-exo-dig-cyclization could be achieved by silver-catalyzed alkyne activation or by oxidation of the intermediate enolate. The mechanistic pathways have been investigated using computational chemistry and mechanistic experiments.
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Registered trials
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