ArticleJournal of materials science. Materials in medicine2016
Biomechanical characterisation of the human nasal cartilages; implications for tissue engineering.
Article in Journal of materials science. Materials in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07717138 (Study of the Biomechanical and Histological Properties of Septal, Auricular, and Costal Cartilage in the Context of Optimizing Total Nasal Reconstruction), which is not on this map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of the Biomechanical and Histological Properties of Septal, Auricular, and Costal Cartilage in the Context of Optimizing Total Nasal Reconstruction
Who cites it
27 citing papers in PubMed, 69 citations in OpenAlex.
- Head and Neck 3D Bioprinting-A Review on Recent Advancements in Soft Tissue 3D Bioprinting and Medical Applications.Journal of functional biomaterials · 2025Review
- Electrocautery for Cartilage Camouflage in Rhinoplasty: A Case Report.World journal of plastic surgery · 2025Article
- Implanted cartilaginous grafts following rhinoplasty: A retrospective histopathological study.Experimental and therapeutic medicine · 2024Article
- Double Reinforcing Strategy with Perpendicular Plate of Ethmoid in Asian Secondary Unilateral Cleft Rhinoplasty: A Finite Element Analysis.Aesthetic plastic surgery · 2024Article
- Human Septal Cartilage Tissue Engineering: Current Methodologies and Future Directions.Bioengineering (Basel, Switzerland) · 2024Review
- M-Shaped Auricular Cartilage Grafts for Correcting Short Nose Deformity in Asians: A Retrospective Study.Aesthetic plastic surgery · 2024Article
- Correction of Short Nose Using M-shaped Cartilage in Asian Patients: Finite Element Analysis and Recommendations for Surgery.Aesthetic plastic surgery · 2023Article
- Investigation on Filaments for 3D Printing of Nasal Septum Cartilage Implant.Materials (Basel, Switzerland) · 2023Article
- Underscoring the effect of swab type, workflow, and positive sample order on swab pooling for COVID-19 surveillance testing.Scientific reports · 2023Article
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- In vivo efficacy of 3D-printed elastin-gelatin-hyaluronic acid scaffolds for regeneration of nasal septal cartilage defects.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Article
- Assessment of a novel patient-specific 3D printed multi-material simulator for endoscopic sinus surgery.Frontiers in bioengineering and biotechnology · 2022Article
- Bimodal Nanocomposite Platform with Antibiofilm and Self-Powering Functionalities for Biomedical Applications.ACS applied materials & interfaces · 2021Article
- Extracellular Matrix Scaffold Using Decellularized Cartilage for Hyaline Cartilage Regeneration.Advances in experimental medicine and biology · 2021Article
- A novel 3D histotypic cartilage construct engineered by supercritical carbon dioxide decellularized porcine nasal cartilage graft and chondrocytes exhibited chondrogenic capabilityInternational journal of medical sciences · 2021Article
- Computational technology for nasal cartilage-related clinical research and application.International journal of oral science · 2020Review
- Ultra-stretchable hydrogels with hierarchical hydrogen bonds.Scientific reports · 2020Article
- Evaluation of human nasal cartilage nonlinear and rate dependent mechanical properties.Journal of biomechanics · 2020Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Nasal reconstruction is currently performed using autologous grafts provides but is limited by donor site morbidity, tissue availability and potentially graft failure. Additionally, current alternative alloplastic materials are limited by their high extrusion and infection rates. Matching mechanical properties of synthetic materials to the native tissue they are replacing has shown to be important in the biocompatibility of implants. To date the mechanical properties of the human nasal cartilages has not been studied in depth to be able to create tissue-engineered replacements with similar mechanical properties to native tissue. The young's modulus was characterized in compression on fresh-frozen human cadaveric septal, alar, and lateral cartilage. Due to the functional differences experienced by the various aspects of the septal cartilage, 16 regions were evaluated with an average elastic modulus of 2.72 ± 0.63 MPa. Furthermore, the posterior septum was found to be significantly stiffer than the anterior septum (p < 0.01). The medial and lateral alar cartilages were tested at four points with an elastic modulus ranging from 2.09 ± 0.81 MPa, with no significant difference between the cartilages (p < 0.78). The lateral cartilage was tested once in all cadavers with an average elastic modulus of 0.98 ± 0.29 MPa. In conclusion, this study provides new information on the compressive mechanical properties of the human nasal cartilage, allowing surgeons to have a better understanding of the difference between the mechanical properties of the individual nasal cartilages. This study has provided a reference, by which tissue-engineered should be developed for effective cartilage replacements for nasal reconstruction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.