Evidence map›Paper›PMID 26676804›Full record

ArticleInternational journal of hematology2016

Molecular genetic and cytogenetic analysis of a primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma.

Keisuke Kato, Yukiko Oh, Junko Takita, Yuji Gunji, Chie Kobayashi, Ai Yoshimi, Tomohei Nakao, Mio Noma, Kazutoshi Koike, Akira Morimoto and 3 more

Abstract readCase Reports
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In one paragraph

Article in International journal of hematology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Keisuke KatoDivision of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Futaba-dai 3-3-1, Mito, Ibaraki, 311-4145, Japan. k-kato@ibaraki-kodomo.com.
Yukiko OhDepartment of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Junko TakitaDepartment of Cell Therapy and Transplantation, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Yuji GunjiDepartment of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Chie KobayashiDivision of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Futaba-dai 3-3-1, Mito, Ibaraki, 311-4145, Japan.
Ai YoshimiDivision of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Futaba-dai 3-3-1, Mito, Ibaraki, 311-4145, Japan.
Tomohei NakaoDivision of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Futaba-dai 3-3-1, Mito, Ibaraki, 311-4145, Japan.
Mio NomaDivision of Cardiovascular Surgery, Ibaraki Children's Hospital, Mito, Japan.
Kazutoshi KoikeDivision of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Futaba-dai 3-3-1, Mito, Ibaraki, 311-4145, Japan.
Akira MorimotoDepartment of Pediatrics, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Shigeko IijimaDivision of Dermatology, Mito Saiseikai Hospital, Mito, Japan.
Hiroshi HojoDivision of Pathology, Fukushima Prefectural University Hospital, Fukushima, Japan.
Masahiro TsuchidaDivision of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Futaba-dai 3-3-1, Mito, Ibaraki, 311-4145, Japan.
Ibaraki Children's Hospital · JPJichi Medical University · JPFutaba (Japan) · JPMito Saiseikai General Hospital · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed cytogenetic and molecular cytogenetic analyses of a primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma, a rare type of primary cutaneous T-cell lymphoma. G-banded analysis at initial diagnosis and recurrence revealed complex karyotype and clonal evolution reflecting genomic instability that parallels the aggressive clinical course observed. Spectral karyotyping revealed numerous structural abnormalities. SNP array-based analysis of an initial diagnostic sample revealed numerous gains and losses of chromosomal material, including loss of short arm of the chromosome 17, to which TP53 is mapped. The molecular cytogenetics and array data of this case suggest genomic instability, particularly chromosomal instability and haploinsufficiency for TP53, the latter possibly giving rise to alteration of p14ARF-Mdm2-p53 tumor suppressor protein pathway, likely to be associated with unfavorable clinical course.

Indexed as

CD8 AntigensCytogenetic AnalysisChildChromosomes, Human, Pair 17FemaleGenomic InstabilityHumansLymphoma, T-Cell, CutaneousPolymorphism, Single NucleotideSpectral KaryotypingTumor Suppressor Protein p53CD8 AntigensTP53 protein, humanTumor Suppressor Protein p53Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphomaSNP array analysisSpectral karyotyping

Identifiers

PMID26676804
OpenAlexW2197454520

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.