Evidence map›Paper›PMID 26676710›Full record

ArticleAmerican journal of primatology2018

Destabilization of the gut microbiome marks the end-stage of simian immunodeficiency virus infection in wild chimpanzees.

Hannah J Barbian, Yingying Li, Miguel Ramirez, Zachary Klase, Iddi Lipende, Deus Mjungu, Andrew H Moeller, Michael L Wilson, Anne E Pusey, Elizabeth V Lonsdorf and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of primatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 42 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Distribution and prevalence ofJournal of medical microbiology · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. ISME communications · 2025
    Article
  9. Local genetic adaptation to habitat in wild chimpanzees.bioRxiv : the preprint server for biology · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. Microbiome Studies in Non-human Primates.Current HIV/AIDS reports · 2021
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. A great-ape view of the gut microbiome.Nature reviews. Genetics · 2019
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Hannah J BarbianDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Yingying LiDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Miguel RamirezDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Zachary KlaseDepartment of Biological Sciences, University of the Sciences, Philadelphia, Pennsylvania.
Iddi LipendeGombe Stream Research Center, Kigoma, Tanzania.
Deus MjunguGombe Stream Research Center, Kigoma, Tanzania.
Andrew H MoellerDepartment of Integrative Biology, University of California, Berkeley, California.
Michael L WilsonDepartment of Anthropology, University of Minnesota, Minneapolis, Minnesota.
Anne E PuseyDepartment of Evolutionary Anthropology, Duke University, Durham, North Carolina.
Elizabeth V LonsdorfDepartment of Psychology, Franklin and Marshall College, Lancaster, Pennsylvania.
Frederic D BushmanDepartment of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Beatrice H HahnDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
University of Pennsylvania · USDuke University · USFranklin & Marshall College · USUniversity of California, Berkeley · USUniversity of Minnesota · USUniversity of the Sciences · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6M
Natural SIV Reservoirs and Human Zoonotic RiskR01AI050529 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2001 to 2022
$6.1M
Molecular Epidemiology and Natural History of SIVcpzR01AI058715 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2004 to 2013
$6.1M
Natural SIV Reservoirs and Human Zoonotic RiskR37AI050529 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2008 to 2017
$5.7M
Training in Emerging Infectious DiseasesT32AI055400 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHERRY, SARA, HENSLEY, SCOTT ERIC · 2003 to 2022
$4.4M
Studies of the precursor of the human AIDS virus in its natural chimpanzee hostR01AI120810 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2016 to 2020
$3.4M
NIAID NIH HHS P30 AI045008NIAID NIH HHS R01 AI050529NIAID NIH HHS R01 AI058715NIAID NIH HHS R01 AI120810NIAID NIH HHS R37 AI050529NIAID NIH HHS T32 AI055400
6 · The paper itself

Abstract

Enteric dysbiosis is a characteristic feature of progressive human immunodeficiency virus type 1 (HIV-1) infection but has not been observed in simian immunodeficiency virus (SIVmac)-infected macaques, including in animals with end-stage disease. This has raised questions concerning the mechanisms underlying the HIV-1 associated enteropathy, with factors other than virus infection, such as lifestyle and antibiotic use, implicated as playing possible causal roles. Simian immunodeficiency virus of chimpanzees (SIVcpz) is also associated with increased mortality in wild-living communities, and like HIV-1 and SIVmac, can cause CD4

Indexed as

Gastrointestinal MicrobiomePan troglodytesAdenoviruses, SimianAnimalsApe DiseasesBacteriaDNA VirusesFecesFemaleMaleMetagenomeRNA, Ribosomal, 16SSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusTanzaniaRNA, Ribosomal, 16SAIDS enteropathychimpanzeesdysbiosisfecal viromegut microbiomeSIVcpz

Identifiers

PMID26676710
PMCPMC4911323
OpenAlexW2298362043

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.