Evidence map›Paper›PMID 26676685›Full record

ArticleMedical & biological engineering & computing2016

Hemodynamic impact of abdominal aortic aneurysm stent-graft implantation-induced stenosis.

Nicolas Aristokleous, Nikolaos G Kontopodis, Konstantinos Tzirakis, Christos V Ioannou, Yannis Papaharilaou

Abstract read
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In one paragraph

Article in Medical & biological engineering & computing, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nicolas AristokleousInstitute of Applied and Computational Mathematics, Foundation for Research and Technology - Hellas, Nikolaou Plastira 100, Vassilika Vouton, 71 110, Heraklion, Crete, Greece.
Nikolaos G KontopodisDepartment of Vascular Surgery, University of Crete Medical School, Heraklion, Crete, Greece.
Konstantinos TzirakisInstitute of Applied and Computational Mathematics, Foundation for Research and Technology - Hellas, Nikolaou Plastira 100, Vassilika Vouton, 71 110, Heraklion, Crete, Greece.
Christos V IoannouDepartment of Vascular Surgery, University of Crete Medical School, Heraklion, Crete, Greece.
Yannis PapaharilaouInstitute of Applied and Computational Mathematics, Foundation for Research and Technology - Hellas, Nikolaou Plastira 100, Vassilika Vouton, 71 110, Heraklion, Crete, Greece. yannisp@iacm.forth.gr.
Foundation for Research and Technology Hellas · GRUniversity of Crete · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current study aims to computationally evaluate the hemodynamic impact of a novel sealing mechanism employed by a recently developed endograft (Ovation TriVascular Stent-Graft System) for endovascular aneurysm repair. The exploitation of two inflatable O-rings to achieve sealing may be advantageous in terms of accommodating challenging anatomies, but comes at a price of a marked inflow stenosis. Here, four representative patient cases of inflow stenosis ranging from 30 to 80 % were analyzed. Lumen surface models were constructed from 1 month post-operative computed tomography images and then used to numerically compute the complex endograft flow field. Our results highlight coexistence of stenotic wall regions exposed to high shear rate and post-stenotic recirculation zones. These conditions may implicate platelet activation and predispose thrombus formation and thromboembolic complications. A clinically insignificant cycle-averaged pressure drop along the inflow stenosis and further in the endograft main body legs was predicted (range 0.01-1.72 mmHg) which was, however, notable at peak systole (range 3.52-19.73 mmHg). Although the functional impact of the endograft stenosis at rest flow conditions may appear insignificant, increased flow rate during exercise is expected to strongly accentuate the observed effects. Pressure drop in the endograft legs was attributed to suboptimal, based on Murray's scaling law, cross-sectional area ratio between trunk and legs of the device.

Indexed as

Aortic Aneurysm, AbdominalComputer SimulationConstriction, PathologicHumansRetrospective StudiesStentsTomography, X-Ray ComputedAbdominal aortic aneurysmEndovascular graftImage-based CFDThrombosis

Identifiers

PMID26676685
OpenAlexW2212416747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.