ReviewThe review of diabetic studies : RDS
Risk Factors and Comorbidities in Diabetic Neuropathy: An Update 2015.
Review in The review of diabetic studies : RDS. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04813133 (Role of Synchronized Lifestyle Modification Program in Peripheral Neuropathy in Insulin Dependent Type 2 Diabetics), which is not on this map. Cited by 88 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Synchronized Lifestyle Modification Program in Peripheral Neuropathy in Insulin Dependent Type 2 Diabetics
Who cites it
88 citing papers in PubMed, 3 syntheses or guidelines pooled it, 205 citations in OpenAlex.
- Omega-3 fatty acid supplementation for distal symmetrical peripheral neuropathy in adults with diabetes mellitus.The Cochrane database of systematic reviews · 2025Pooled it
- Bidirectional association between periodontal disease and diabetes mellitus: a systematic review and meta-analysis of cohort studies.Scientific reports · 2021Pooled it
- Pooled it
- Nonpharmaceutical treatment of distal sensorimotor polyneuropathy in diabetic patients: an unblinded randomized clinical trial.BMC complementary medicine and therapies · 2025Trial
- Acupuncture in diabetic peripheral neuropathy-neurological outcomes of the randomized acupuncture in diabetic peripheral neuropathy trial.World journal of diabetes · 2023Trial
- Reduced heart rate variability predicts incident diabetic polyneuropathy.Frontiers in endocrinology · 2026Article
- Self-efficacy, Knowledge and Outcomes Expectations Foot Self-care among Diabetic Patients with High-Risk Feet in Jordan.Current diabetes reviews · 2026Article
- Estimating the Risk of Lower Extremity Complications in Adults Newly Diagnosed With Diabetic Polyneuropathy: Retrospective Cohort Study.JMIR diabetes · 2025Article
- Investigating Awareness, Risk Factors, and Management of Diabetic Peripheral Neuropathy: An All-Inclusive Cross-Sectional Study in Saudi Arabia.Journal of pharmacy & bioallied sciences · 2025Article
- Effectiveness of Vitamin B1-6-12 Supplementation Compared With Vitamin B12 and Gabapentin in Patients With Diabetic Peripheral Neuropathy.Clinical diabetes : a publication of the American Diabetes Association · 2025Article
- Commentary on "Diminished levels of insulin-like growth factor-1 may be a risk factor for peripheral neuropathy in type 2 diabetes patients".Journal of diabetes investigation · 2025Article
- Commentary on "Prognostic value of longitudinal HbA1c variability in predicting the development of diabetic sensorimotor polyneuropathy among patients with type 2 diabetes mellitus: A prospective cohort observational study".Journal of diabetes investigation · 2025Article
- Healthcare costs and medical utilization patterns associated with painful and severe painful diabetic peripheral neuropathy.Endocrine · 2024Article
- The Social Determinants of Health in a Cohort of Romanian Patients with Diabetic and Nondiabetic Neuropathy.Journal of clinical medicine · 2024Article
- Phase Angle of Bioelectrical Impedance Analysis as an Indicator for Diabetic Polyneuropathy in Type 2 Diabetes Mellitus.The Journal of clinical endocrinology and metabolism · 2024Observational
- Role of Decreased Expression of miR-155 and miR-146a in Peripheral Blood of Type 2 Diabetes Mellitus Patients with Diabetic Peripheral Neuropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Vitamin D Deficiency Participates in Depression of Patients with Diabetic Peripheral Neuropathy by Regulating the Expression of Pro-Inflammatory Cytokines.Neuropsychiatric disease and treatment · 2024Article
- Expert consensus guidelines for community pharmacists in the management of diabetic peripheral neuropathy with a combination of neurotropic B vitamins.Journal of pharmaceutical policy and practice · 2024Review
- Diabetic peripheral neuropathy: age-stratified glycemic control.Frontiers in endocrinology · 2024Article
- Peripheral Arterial Disease is Associated with Sensorimotor Peripheral Neuropathy in People with Type 2 Diabetes.Medical journal of the Islamic Republic of Iran · 2024Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Distal symmetric sensorimotor polyneuropathy (DSPN) is the most common neurological manifestation in diabetes. Major risk factors of DSPN include diabetes duration, hyperglycemia, and age, followed by prediabetes, hypertension, dyslipidemia, and obesity. Height, smoking, insulin resistance, hypoinsulinemia, and others represent an additional risk. Importantly, hyperglycemia, hypertension, dyslipidemia, obesity, and smoking are modifiable. Stringent glycemic control has been shown to be effective in type 1, but not to the same extent in type 2 diabetes. Antilipidemic treatment, especially with fenofibrate, and multi-factorial intervention have produced encouraging results, but more experience is necessary. The major comorbidities of DSPN are depression, autonomic neuropathy, peripheral arterial disease, cardiovascular disease, nephropathy, retinopathy, and medial arterial calcification. Knowledge of risk factors and comorbidities has the potential to enrich the therapeutic strategy in clinical practice as part of the overall medical care for patients with neuropathy. This article provides an updated overview of DSPN risk factors and comorbidities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.