ArticleImmunologic research2016
Gluten ataxia is better classified as non-celiac gluten sensitivity than as celiac disease: a comparative clinical study.
Article in Immunologic research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Cerebellar Symptoms in Gluten Sensitivity: a Systematic Review of the Effect of a Gluten-Free Diet on Brain Imaging.Cerebellum (London, England) · 2022Pooled it
- Pooled it
- Presumptive paroxysmal dyskinesia in 41 dogs: is the diet change enough?Journal of veterinary internal medicine · 2026Article
- Non-Coeliac Wheat Sensitivity: Symptoms in Search of a Mechanism, or a Distinct Well-Defined Clinical Entity? A Narrative Review.International journal of molecular sciences · 2025Review
- Investigating Non-celiac Wheat Sensitivity: A Comprehensive Review of Pathophysiology Underlying Clinical Implications.Clinical reviews in allergy & immunology · 2025Review
- Celiac Disease-Narrative Review on Progress in Celiac Disease.Foods (Basel, Switzerland) · 2025Review
- Paediatric gluten ataxia: a rare neurological presentation of gluten sensitivity in a toddler.BMJ case reports · 2025Article
- Gluten-Free Diet Adherence Evaluation in Adults with Long-Standing Celiac Disease.Foods (Basel, Switzerland) · 2024Article
- Evaluation of the Prevalence of Anti-transglutaminase 2 and 6 Antibodies in Patients with Sero-Positive Multiple Sclerosis.Middle East journal of digestive diseases · 2024Article
- Autoantibody Encephalitis: Presentation, Diagnosis, and Management.Journal of clinical neurology (Seoul, Korea) · 2022Review
- Neurological manifestation of coeliac disease with particular emphasis on gluten ataxia and immunological injury: a review article.Gastroenterology and hepatology from bed to bench · 2021Review
- Celiac Disease Diagnosed in an Older Adult Patient with a Complex Neuropsychiatric Involvement: A Case Report and Review of the Literature.Brain sciences · 2020Article
- Does celiac disease cause autoimmune sensorineural hearing loss?The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
- Non-Celiac Gluten Sensitivity: A Review.Medicina (Kaunas, Lithuania) · 2019Review
- Review
- Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm.World journal of gastroenterology · 2018Review
- Properties of Gluten Intolerance: Gluten Structure, Evolution, Pathogenicity and Detoxification Capabilities.Nutrients · 2016Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gluten ataxia (GA) has customarily been considered to be the main neurological manifestation of celiac disease (CD). In recent years, the condition of non-celiac gluten sensitivity (NCGS) has been defined, which includes some patients who are not considered "true celiacs." We performed a comparative clinicopathological study of these three entities. We studied 31 GA, 48 CD and 37 NCGS patients, prospectively in the same center for a period of 7 years. The protocol study included two serological determinations for gluten sensitivity [anti-gliadin IgA and IgG (AGA) and anti-tissue transglutaminase IgA (TG) antibodies], HLA-DQ2 typing, and duodenal histological assessment. Demographics and investigative findings were compared. Females were 55 % in GA, 75 % in CD (p < 0.001), and 47 % in NCGS (N.S.). GA patients were older (59 ± 14 years) than CD (43 ± 13 years) and NCGS (41 ± 8 years) groups (p < 0.001). AGA positivity was higher in GA (100 %) than in CD (48 %) groups (p < 0.001), but similar to NCGS patients (89 %; N.S.); TG positivity was lower in GA (3.2 %) than in CD (33.3 %; p < 0.001), but similar to NCGS (2.7 %; N.S.). DQ2 (+) was lower in GA (32.2 %) than in CD (89.6 %; p < 0.001), but similar to NCGS (29.7 %; N.S.). Lymphocytic enteritis (Marsh type 1) was lower in GA (9.6 %) than in CD (66.7 %; p < 0.001), but similar to NCGS (10.8 %; N.S.). The other gluten sensitivity-related characteristics measured were different to CD patients, but very close to NCGS. We conclude that GA patients are better classified within the NCGS group, than within CD.
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