ArticleMolecular medicine reports2016
Differential lncRNA‑mRNA co‑expression network analysis revealing the potential regulatory roles of lncRNAs in myocardial infarction.
Article in Molecular medicine reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Fusion of multi-source relationships and topology to infer lncRNA-protein interactions.Molecular therapy. Nucleic acids · 2024Article
- Progress and trends in myocardial infarction-related long non-coding RNAs: a bibliometric analysis.Frontiers in molecular biosciences · 2024Review
- Activity-Dependent Non-Coding RNA MAPK Interactome of the Human Epileptic Brain.Non-coding RNA · 2023Article
- Article
- Article
- Solamargine Inhibits the Development of Hypopharyngeal Squamous Cell Carcinoma by Decreasing LncRNAFrontiers in pharmacology · 2022Article
- Downregulation of Long Noncoding RNA LINC00261 Attenuates Myocardial Infarction through the miR-522-3p/Trinucleotide Repeat-Containing Gene 6a (TNRC6A) Axis.Cardiovascular therapeutics · 2021Article
- A genome-wide identification, characterization and functional analysis of salt-related long non-coding RNAs in non-model plant Pistacia vera L. using transcriptome high throughput sequencing.Scientific reports · 2020Article
- Comprehensive analysis of differentially expressed lncRNAs as diagnostic and prognostic markers for colorectal cancer.Experimental and therapeutic medicine · 2019Article
- Expression profiles and potential functions of long non-coding RNA in stable angina pectoris patients from Uyghur population of China.Bioscience reports · 2019Article
- Expression profiles of long noncoding RNAs associated with the NSUN2 gene in HepG2 cells.Molecular medicine reports · 2019Article
- Expression profiles of long noncoding RNAs and messenger RNAs in the border zone of myocardial infarction in rats.Cellular & molecular biology letters · 2019Article
- The long noncoding RNA THRIL knockdown protects hypoxia-induced injuries of H9C2 cells through regulating miR-99a.Cardiology journal · 2019Article
- Bioinformatic screening for key miRNAs and genes associated with myocardial infarction.FEBS open bio · 2018Article
- Identification of aberrantly expressed long non-coding RNAs in postmenopausal osteoporosis.International journal of molecular medicine · 2018Article
- Differential expression profiles of long non-coding RNAs as potential biomarkers for the early diagnosis of acute myocardial infarction.Oncotarget · 2017Article
- Systematic comparison of lncRNAs with protein coding mRNAs in population expression and their response to environmental change.BMC plant biology · 2017Article
- Environmental Health and Long Non-coding RNAs.Current environmental health reports · 2016Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have reported that long, non‑coding RNAs (lncRNAs) are important in cardiovascular disease. However, the lncRNAs involved in myocardial infarction and their detailed mechanism have not been well characterized. In the present study, an affymetrix microarray associated with myocardial infarction was re‑annotated, following which a myocardial infarction‑related differential lncRNA‑mRNA co‑expression network (MILMN) was constructed. Subsequently, pathway enrichment analysis was used for all the mRNAs in the MILMN, and an lncRNA‑pathway network was constructed. It was found that the mRNAs were predominantly involved in certain cardiovascular disease‑associated pathway, for example the dilated cardiomyopathy and mitogen‑activated protein kinase signaling pathway. Finally, a total of 39 key lncRNAs were identified, which regulate crucial pathways in myocardial infarction. Through pathway analysis of these 39 key lncRNAs, the novel function of an annotated lncRNAs‑H19 was predicted, which may regulate apoptosis signal‑regulating kinase, which is a protein that promotes pathological cardiac remodeling following myocardial infarction. The results of the present study not only provide potential non‑coding RNA biomarkers, but also provide further insights into understanding the molecular mechanism of lncRNAs.
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