ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2016
Pudendal but not tibial nerve stimulation inhibits bladder contractions induced by stimulation of pontine micturition center in cats.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Influence of transcutaneous tibial nerve stimulation on postoperative catheter-related bladder discomfort in urology: a prospective randomized controlled trial.Scientific reports · 2025Trial
- Exploratory research on efficacy and safety of a fine-needle tibial nerve stimulator for treating overactive bladder in cats.International urology and nephrology · 2026Article
- Seventy-Five Years of NIH NIDDK Funding Has Increased Knowledge and Greatly Impacted Clinical Care.Neurourology and urodynamics · 2026Review
- The impact of transcutaneous tibial nerve stimulation on brain function in patients with overactive bladder: a prospective longitudinal self-controlled study.Frontiers in human neuroscience · 2026Article
- The mechanism of action of neuromodulation in the treatment of overactive bladder.Nature reviews. Urology · 2025Review
- Effects of different pulse widths on acute tibial nerve stimulation for overactive bladder in cats.European journal of medical research · 2025Article
- Pathways and parameters of sacral neuromodulation in rats.American journal of physiology. Renal physiology · 2023Article
- Role of opioid and β-adrenergic receptors in bladder underactivity induced by prolonged pudendal nerve stimulation in cats.Neurourology and urodynamics · 2023Article
- Bladder underactivity induced by prolonged pudendal afferent activity in cats.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Spinal interneuronal mechanisms underlying pudendal and tibial neuromodulation of bladder function in cats.Experimental neurology · 2018Article
- Sacral neuromodulation blocks pudendal inhibition of reflex bladder activity in cats: insight into the efficacy of sacral neuromodulation in Fowler's syndrome.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- An excitatory reflex from the superficial peroneal nerve to the bladder in cats.American journal of physiology. Renal physiology · 2017Article
- Lumbosacral spinal segmental contributions to tibial and pudendal neuromodulation of bladder overactivity in cats.Neurourology and urodynamics · 2017Article
- Effectiveness of percutaneous tibial nerve stimulation in the treatment of overactive bladder syndrome.Research and reports in urology · 2017Review
- Sympathetic β-adrenergic mechanism in pudendal inhibition of nociceptive and non-nociceptive reflex bladder activity.American journal of physiology. Renal physiology · 2016Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 2 countries.
Funding
Abstract
This study examined the possibility that pudendal nerve stimulation (PNS) or tibial nerve stimulation (TNS) inhibits the excitatory pathway from the pontine micturition center (PMC) to the urinary bladder. In decerebrate cats under α-chloralose anesthesia, electrical stimulation of the PMC (40 Hz frequency, 0.2-ms pulse width, 10-25 s duration) using a microelectrode induced bladder contractions >20 cmH2O amplitude when the bladder was filled to 60-70% capacity. PNS or TNS (5 Hz, 0.2 ms) at two and four times the threshold (2T and 4T) to induce anal or toe twitch was applied to inhibit the PMC stimulation-induced bladder contractions. Propranolol, a nonselective β-adrenergic receptor antagonist, was administered intravenously (1 mg/kg i.v.) to determine the role of sympathetic pathways in PNS/TNS inhibition. PNS at both 2T and 4T significantly (P < 0.05) reduced the amplitude and area under the curve of the bladder contractions induced by PMC stimulation, while TNS at 4T facilitated the bladder contractions. Propranolol completely eliminated PNS inhibition and TNS facilitation. This study indicates that PNS, but not TNS, inhibits PMC stimulation-induced bladder contractions via a β-adrenergic mechanism that may occur in the detrusor muscle as a result of reflex activity in lumbar sympathetic nerves. Neither PNS nor TNS activated a central inhibitory pathway with synaptic connections to the sacral parasympathetic neurons that innervate the bladder. Understanding the site of action involved in bladder neuromodulation is important for developing new therapies for bladder disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.