Evidence map›Paper›PMID 26676250›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2016

Vitamin D supplementation improves pathophysiology in a rat model of preeclampsia.

Jessica L Faulkner, Denise C Cornelius, Lorena M Amaral, Ashlyn C Harmon, Mark W Cunningham, Marie M Darby, Tarek Ibrahim, D'Andrea S Thomas, Florian Herse, Gerd Wallukat and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

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  16. Vitamin D supplementation reduces some AT1-AA-induced downstream targets implicated in preeclampsia including hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Jessica L FaulknerDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi;
Denise C CorneliusDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi;
Lorena M AmaralDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi;
Ashlyn C HarmonDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi;
Mark W CunninghamDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi;
Marie M DarbyDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi;
Tarek IbrahimDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi;
D'Andrea S ThomasDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi;
Florian HerseExperimental and Clinical Research Center, Charité Campus Buch and Max-Delbrück Center for Molecular Medicine, Berlin, Germany; and.
Gerd WallukatExperimental and Clinical Research Center, Charité Campus Buch and Max-Delbrück Center for Molecular Medicine, Berlin, Germany; and.
Ralf DechendExperimental and Clinical Research Center, Charité Campus Buch and Max-Delbrück Center for Molecular Medicine, Berlin, Germany; and HELIOS Clinic, Department of Cardiology and Nephrology, Berlin, Germany.
Babbette LaMarcaDepartment of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi; Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi; bblamarca@umc.edu.
University of Mississippi Medical Center · USMax Delbrück Center · DECharité - Universitätsmedizin Berlin · DE

Funding

STRUCTURAL VASCULAR ADAPTATION OF THE MICROCIRCULATIONP01HL051971 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI RECKELHOFF, JANE F · 1993 to 2018
$39.4M
Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
The Kidney, Hypertension, Pregnancy and InflammationR01HD067541 · NICHD · UNIVERSITY OF MISSISSIPPI MED CTR · PI LAMARCA, BABBETTE · 2011 to 2020
$3.1M
Mechanisms of Pregnancy Induced HypertensionF32HL078147 · NHLBI · UNIVERSITY OF MISSISSIPPI MEDICAL CENTER · PI LAMARCA, BABBETTE · 2005 to 2007
$149k
NHLBI NIH HHS HL-105324NHLBI NIH HHS HL-124715NHLBI NIH HHS HL-51971NHLBI NIH HHS HL-78147NHLBI NIH HHS T32 HL105324NICHD NIH HHS HD-067541NICHD NIH HHS R01 HD067541
6 · The paper itself

Abstract

Deficiency of vitamin D (VD) is associated with preeclampsia (PE), a hypertensive disorder of pregnancy characterized by proinflammatory immune activation. We sought to determine whether VD supplementation would reduce the pathophysiology and hypertension associated with the reduced uterine perfusion pressure (RUPP) rat model of PE. Normal pregnant (NP) and RUPP rats were supplemented with VD2 or VD3 (270 IU and 15 IU/day, respectively) on gestation days 14-18 and mean arterial pressures (MAPs) measured on day 19. MAP increased in RUPP to 123 ± 2 mmHg compared with 102 ± 3 mmHg in NP and decreased to 113 ± 3 mmHg with VD2 and 115 ± 3 mmHg with VD3 in RUPP rats. Circulating CD4+ T cells increased in RUPP to 7.90 ± 1.36% lymphocytes compared with 2.04 ± 0.67% in NP but was lowered to 0.90 ± 0.19% with VD2 and 4.26 ± 1.55% with VD3 in RUPP rats. AT1-AA, measured by chronotropic assay, decreased from 19.5 ± 0.4 bpm in RUPPs to 8.3 ± 0.5 bpm with VD2 and to 15.4 ± 0.7 bpm with VD3. Renal cortex endothelin-1 (ET-1) expression was increased in RUPP rats (11.6 ± 2.1-fold change from NP) and decreased with both VD2 (3.3 ± 1.1-fold) and VD3 (3.1 ± 0.6-fold) supplementation in RUPP rats. Plasma-soluble FMS-like tyrosine kinase-1 (sFlt-1) was also reduced to 74.2 ± 6.6 pg/ml in VD2-treated and 91.0 ± 16.1 pg/ml in VD3-treated RUPP rats compared with 132.7 ± 19.9 pg/ml in RUPP rats. VD treatment reduced CD4+ T cells, AT1-AA, ET-1, sFlt-1, and blood pressure in the RUPP rat model of PE and could be an avenue to improve treatment of hypertension in response to placental ischemia.

Indexed as

Dietary SupplementsAnimalsArterial PressureBirth WeightCD4-Positive T-LymphocytesEndothelin-1FemaleIschemiaKidneyLymphocyte CountPre-EclampsiaPregnancyRatsReceptor, Angiotensin, Type 1Regional Blood FlowUterusEndothelin-1Flt1 protein, ratReceptor, Angiotensin, Type 1Vascular Endothelial Growth Factor Receptor-1Vitamin DVitaminshypertensionimmune activationpreeclampsiavitamin D

Identifiers

PMID26676250
PMCPMC4796742
OpenAlexW2221145105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.