Evidence map›Paper›PMID 26676172›Full record

ArticleBBA clinical2015

Skeletal muscle microvascular function in girls with Turner syndrome.

Sarah L West, Clodagh S O'Gorman, Alyaa H Elzibak, Jessica Caterini, Michael D Noseworthy, Tammy Rayner, Jill Hamilton, Greg D Wells

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BBA clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Guideline
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sarah L WestFaculty of Kinesiology and Physical Education, The University of Toronto, Canada ; Physiology and Experimental Medicine, The Hospital for Sick Children, Canada.
Clodagh S O'GormanPhysiology and Experimental Medicine, The Hospital for Sick Children, Canada ; Division of Endocrinology, The Hospital for Sick Children, The University of Toronto, Canada.
Alyaa H ElzibakPhysiology and Experimental Medicine, The Hospital for Sick Children, Canada.
Jessica CateriniFaculty of Kinesiology and Physical Education, The University of Toronto, Canada.
Michael D NoseworthySchool of Biomedical Engineering, McMaster University, Canada ; Department of Electrical and Computer Engineering, McMaster University, Canada.
Tammy RaynerDepartment of Diagnostic Imaging, The Hospital for Sick Children, Canada.
Jill HamiltonDivision of Endocrinology, The Hospital for Sick Children, The University of Toronto, Canada.
Greg D WellsFaculty of Kinesiology and Physical Education, The University of Toronto, Canada ; Physiology and Experimental Medicine, The Hospital for Sick Children, Canada.
Hospital for Sick Children · CAUniversity of Toronto · CAMcMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise intolerance is prevalent in individuals with Turner Syndrome (TS). We recently demonstrated that girls with TS have normal aerobic but altered skeletal muscle anaerobic metabolism compared to healthy controls (HC). The purpose of this study was to compare peripheral skeletal muscle microvascular function in girls with TS to HC after exercise. We hypothesized that girls with TS would have similar muscle blood-oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) signal responses during recovery from exercise compared to HC.

methodsThirteen TS participants and 8 HC completed testing. BOLD MRI was used to measure skeletal muscle microvascular response during 60 second recovery, following 60 s of exercise at 65% of maximal workload. Exercise and recovery were repeated four times, and the BOLD signal time course was fit to a four-parameter sigmoid function.

resultsParticipants were 13.7 ± 3.1 years old and weighed 47.9 ± 14.6 kg. The mean change in BOLD signal intensity following exercise at the end of recovery, the mean response time of the function/the washout of deoxyhemoglobin, and the mean half-time of recovery were similar between the TS and HC groups.

conclusionsOur results demonstrate that compared to HC, peripheral skeletal muscle microvascular function following exercise in girls with TS is not impaired. GENERAL SIGNIFICANCE: This study supports the idea that the aerobic energy pathway is not impaired in children with TS in response to submaximal exercise. Other mechanisms are likely responsible for exercise intolerance in TS; this needs to be further investigated.

Indexed as

BOLD MRIExerciseMicrovascular functionPediatricSkeletal muscleTurner syndrome

Identifiers

PMID26676172
PMCPMC4661506
OpenAlexW2038629292

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.