ArticleBBA clinical2015
A novel approach to study oxidative stress in neonatal respiratory distress syndrome.
Article in BBA clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06559670 (Prevention of Chronic Lung Disease), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Chronic Lung Disease: New High Risk Profile for Early Detection and Management Starting From Perinatal Life (CLD - Prevention Study)
Who cites it
24 citing papers in PubMed, 40 citations in OpenAlex.
- Hyperoxia During Neonatal Cardiopulmonary Bypass Is Associated With Worse Clinical Outcomes: A Multi-Institutional Study.Journal of the American Heart Association · 2026Article
- Moderate-to-late prematurity: understanding respiratory consequences and modifiable risk factors.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Oxidative Stress in Pregnancy.Biomolecules · 2023Review
- Article
- Biomarkers of Oxidative Stress in Healthy Infants within the First Three Days after Birth.Antioxidants (Basel, Switzerland) · 2023Article
- Association between thiol-disulfide hemostasis and transient tachypnea of the newborn in late-preterm and term infants.BMC pediatrics · 2023Article
- Antenatal and Postnatal Sequelae of Oxidative Stress in Preterm Infants: A Narrative Review Targeting Pathophysiological Mechanisms.Antioxidants (Basel, Switzerland) · 2023Review
- Human Milk Feeding for Septic Newborn Infants Might Minimize Their Exposure to Ventilation Therapy.Children (Basel, Switzerland) · 2022Article
- Evaluation of Genetic Polymorphisms of the Antioxidant Enzymes and Biomarkers of Oxidative Stress in Preterm Neonates With Respiratory Distress Syndrome Receiving External Surfactant.Biomarker insights · 2022Article
- Oxidative Stress and Respiratory Diseases in Preterm Newborns.International journal of molecular sciences · 2021Review
- Oxidative Stress in Preterm Newborns.Antioxidants (Basel, Switzerland) · 2021Review
- Oxidative Stress at Birth Is Associated with the Concentration of Iron and Copper in Maternal Serum.Nutrients · 2021Article
- Efficacy comparison of high-frequency oscillatory ventilation with continuous nasal positive airway pressure in neonatal respiratory distress syndrome treatment.American journal of translational research · 2021Article
- Biomarkers of Oxidative Stress for Neonatal Lung Disease.Frontiers in pediatrics · 2021Review
- Relationship Between Oxidative Stress Markers and Endothelin-1 Levels in Newborns of Different Gestational Ages.Frontiers in pediatrics · 2020Article
- Oxidative stress markers in neonatal respiratory distress syndrome: advanced oxidation protein products and 8-hydroxy-2-deoxyguanosine in relation to disease severity.Pediatric research · 2020Article
- Antioxidant Capacity of Preterm Neonates Assessed by Hydrogen Donor Value.Medicina (Kaunas, Lithuania) · 2019Observational
- Oxidative Stress and Anti-Oxidant Markers in Premature Infants with Respiratory Distress Syndrome.Open access Macedonian journal of medical sciences · 2019Article
- Autism Spectrum Disorders and Perinatal Complications-Is Oxidative Stress the Connection?Frontiers in psychiatry · 2019Article
- Serum glutathione S-transferase Pi as predictor of the outcome and acute kidney injury in premature newborns.Pediatric nephrology (Berlin, Germany) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRespiratory distress syndrome of the neonate (neonatal RDS) is still an important problem in treatment of preterm infants. It is accompanied by inflammatory processes with free radical generation and oxidative stress. The aim of study was to determine the role of oxidative stress in the development of neonatal RDS.
methodsMarkers of oxidative stress and antioxidant activity in umbilical cord blood were studied in infants with neonatal respiratory distress syndrome with reference to healthy newborns.
resultsStatus of markers of oxidative stress (malondialdehyde, protein carbonyl and 8-hydroxy-2-deoxy guanosine) showed a significant increase with depleted levels of total antioxidant capacity in neonatal RDS when compared to healthy newborns.
conclusionThe study provides convincing evidence of oxidative damage and diminished antioxidant defenses in newborns with RDS. Neonatal RDS is characterized by damage of lipid, protein and DNA, which indicates the augmentation of oxidative stress. GENERAL SIGNIFICANCE: The identification of the potential biomarker of oxidative stress consists of a promising strategy to study the pathophysiology of neonatal RDS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.