Evidence map›Paper›PMID 26676067›Full record

ReviewJournal of cachexia, sarcopenia and muscle2015

Loss of muscle mass: current developments in cachexia and sarcopenia focused on biomarkers and treatment.

Cathleen Drescher, Masaaki Konishi, Nicole Ebner, Jochen Springer

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Journal of cachexia, sarcopenia and muscle, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07362329 (Use of Resistive Exercise Snacks to Improve Upper Body Fitness in Graduate Students), which is not on this map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07362329 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

Use of Resistive Exercise Snacks to Improve Upper Body Fitness in Graduate Students

TypeinterventionalSponsorNew York Institute of TechnologyRan2026 to 2026Enrolled50ConditionsMuscle Strength, Muscle Power, Physical EnduranceArmsSubmaximal Repeated Exercise Snack, Maximal One-Time Exercise Snack
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 94 citations in OpenAlex.

  1. Trial
  2. Creatine ( methyl-dJournal of applied physiology (Bethesda, Md. : 1985) · 2018
    Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. J-shaped relationship between serum creatinine and mortality in Korean patients with acute heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2025
    Observational
  8. Wearable Bioelectronics for Home-Based Monitoring and Treatment of Muscle Atrophy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  9. Article
  10. The link between Mitochondria and Sarcopenia.Journal of physiology and biochemistry · 2025
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Cathleen DrescherInnovative Clinical Trials, Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG) Göttingen, Germany.
Masaaki KonishiInnovative Clinical Trials, Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG) Göttingen, Germany.
Nicole EbnerInnovative Clinical Trials, Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG) Göttingen, Germany.
Jochen SpringerInnovative Clinical Trials, Department of Cardiology and Pneumology, University Medical Center Göttingen (UMG) Göttingen, Germany.
Universitätsmedizin Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loss of muscle mass arises from an imbalance of protein synthesis and protein degradation. Potential triggers of muscle wasting and function are immobilization, loss of appetite, dystrophies, and chronic diseases as well as aging. All these conditions lead to increased morbidity and mortality in patients, which makes it a timely matter to find new biomarkers to get a fast clinical diagnosis and to develop new therapies. This mini-review covers current developments in the field of biomarkers and drugs on cachexia and sarcopenia. Here, we reported about promising markers, e.g. tartate-resistant acid phosphatase 5a, and novel substances like epigallocatechin-3-gallate. In summary, the progress to combat muscle wasting is in full swing, and perhaps diagnosis of muscle atrophy and of course patient treatments could be soon support by improved and more helpful strategies.

Indexed as

BiomarkerCachexiaMuscle wastingSarcopeniaTreatment

Identifiers

PMID26676067
PMCPMC4670737
OpenAlexW2175926612

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.