Evidence map›Paper›PMID 26676041›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2016

Mini-Osmotic Pump Infusion Model to Investigate the Systemic Effects of Chronic Continuous Exposure to Staphylococcal Superantigen in Mice.

Ashton L Krogman, Vaidehi Chowdhary, Govindarajan Rajagopalan

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 81% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Protective Role ofFrontiers in pharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ashton L KrogmanDepartment of Immunology, Mayo Clinic, Rochester, MN, USA.
Vaidehi ChowdharyDivision of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Govindarajan RajagopalanDepartment of Immunology, Mayo Clinic, Rochester, MN, USA. Rajagopalan.govindarajan@mayo.edu.
Mayo Clinic · USMayo Clinic in Arizona · US

Funding

HLA class II transgenic mouse models for S. aureus infections and superantigensR01AI068741 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI RAJAGOPALAN, GOVINDARAJAN · 2007 to 2016
$3.1M
Role of HLA-DR3 in Pathogenesis of Systemic Lupus Erythematosus (SLE)K23AR057815 · NIAMS · MAYO CLINIC ROCHESTER · PI CHOWDHARY, VAIDEHI RADHAKRISHNA · 2010 to 2014
$642k
Novel Combination Therapy for Staphylococcus aureus PneumoniaR21AI101172 · NIAID · MAYO CLINIC ROCHESTER · PI RAJAGOPALAN, GOVINDARAJAN · 2012 to 2013
$425k
NIAID NIH HHS AI101172NIAID NIH HHS AI68741NIAID NIH HHS R01 AI068741NIAID NIH HHS R21 AI101172NIAMS NIH HHS 5K23AR057815-02NIAMS NIH HHS K23 AR057815
6 · The paper itself

Abstract

Staphylococcus aureus can exist as a colonizer or can cause a spectrum of diseases. S. aureus elaborates several exotoxins and the superantigens are one among them. Staphylococcal superantigens (SSAg) cause robust activation of the immune system and acute exposure to significant amounts of SSAg can be potentially lethal. However, chronic exposure to SSAg is also possible. Administering SSAg using mini-osmotic pumps may mimic chronic recurrent exposure to SSAg. This is a relatively simple and safe way to administer purified SSAg or any other toxin/agent. In this chapter, we describe the mini-osmotic pump-mediated delivery of SSAg.

Indexed as

Disease Models, AnimalAnimalsInfusion Pumps, ImplantableMiceStaphylococcal InfectionsStaphylococcusSuperantigensSuperantigensMini-osmotic pumpStaphylococcus aureusSuperantigen

Identifiers

PMID26676041
PMCPMC4882905
OpenAlexW2437304998

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.