Evidence map›Paper›PMID 26675822›Full record

ReviewNature reviews. Neuroscience2016

Neurobiology of rodent self-grooming and its value for translational neuroscience.

Allan V Kalueff, Adam Michael Stewart, Cai Song, Kent C Berridge, Ann M Graybiel, John C Fentress

Erratum issuedOpen access · bronzeAbstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 408 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
408citing papers in PubMed, 1 pooled it
54.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

408 citing papers in PubMed, 1 synthesis or guideline pooled it, 836 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. A Gut-Brain Axis Underlying Succinate-Associated Compulsive-Like Behavior.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Lateral septal PACAP signaling regulates stress and anxiety reactions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  11. Article
  12. Article
  13. 5-HTZoological research · 2026
    Article
  14. Article
  15. Article
  16. Age-Associated Behavioral Alterations in Laboratory-Housed Octodon degus.bioRxiv : the preprint server for biology · 2026
    Article
  17. Article
  18. Grooming as a window into the post-stress recuperative process.bioRxiv : the preprint server for biology · 2026
    Article
  19. Article
  20. Article

348 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Allan V KalueffResearch Institute of Marine Drugs and Nutrition, Key Laboratory of Aquatic Product Processing and Safety, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Adam Michael StewartNeuroscience Research Laboratory, ZENEREI Research Center, Slidell, Louisiana 70458, USA.
Cai SongResearch Institute of Marine Drugs and Nutrition, Key Laboratory of Aquatic Product Processing and Safety, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
Kent C BerridgeDepartment of Psychology, University of Michigan, 525E University Str, Ann Arbor, Michigan 48109, USA.
Ann M GraybielMcGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, Massachusetts 02139, USA.
John C FentressDepartment of Psychology and Neuroscience, Dalhousie University, 1355 Oxford St, Life Sciences Centre, Halifax, Nova Scotia B3H4R2, Canada.
Dalhousie University · CAMcGovern Institute for Brain Research · USSt Petersburg University · RUUniversity of Michigan–Ann Arbor · US

Funding

Functional and anatomical characterization of the striosomal systemR01MH060379 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Ann M Graybiel · 2000 to 2026
$8.7M
Affective neuroscience of taste reactivityR01MH063649 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERRIDGE, KENT C. · 2002 to 2024
$7.8M
STUDIES ON THE EXTRAPYRAMIDAL SYSTEMR01NS025529 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRAYBIEL, ANN M · 1988 to 2017
$5.6M
Cue-triggered Reward SeekingR01DA015188 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERRIDGE, KENT C. · 2003 to 2021
$4.9M
Novel Second Messenger Signaling in the StriatumR37HD028341 · NICHD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRAYBIEL, ANN M · 2004 to 2013
$3.8M
NOVEL SECOND MESSENGER SIGNALING IN THE STRIATUMR01HD028341 · NICHD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRAYBIEL, ANN M · 1992 to 2003
$1.3M
Extrapyramidal SystemsR56NS025529 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRAYBIEL, ANN M · 2008 to 2008
$175k
NICHD NIH HHS HD028341NICHD NIH HHS R01 HD028341NICHD NIH HHS R37 HD028341NIDA NIH HHS DA015188NIDA NIH HHS R01 DA015188NIMH NIH HHS MH060379NIMH NIH HHS MH63649NIMH NIH HHS R01 MH060379NIMH NIH HHS R01 MH063649NINDS NIH HHS NS025529NINDS NIH HHS R01 NS025529NINDS NIH HHS R56 NS025529
6 · The paper itself

Abstract

Self-grooming is a complex innate behaviour with an evolutionarily conserved sequencing pattern and is one of the most frequently performed behavioural activities in rodents. In this Review, we discuss the neurobiology of rodent self-grooming, and we highlight studies of rodent models of neuropsychiatric disorders--including models of autism spectrum disorder and obsessive compulsive disorder--that have assessed self-grooming phenotypes. We suggest that rodent self-grooming may be a useful measure of repetitive behaviour in such models, and therefore of value to translational psychiatry. Assessment of rodent self-grooming may also be useful for understanding the neural circuits that are involved in complex sequential patterns of action.

Indexed as

NeurobiologyAnimalsAutism Spectrum DisorderBehavior, AnimalDisease Models, AnimalGroomingHumansObsessive-Compulsive Disorder

Identifiers

PMID26675822
PMCPMC4840777
OpenAlexW2205794177

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.