Trial reportThe American journal of clinical nutrition2016
Genetic polymorphisms that affect selenium status and response to selenium supplementation in United Kingdom pregnant women.
Trial report in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Micronutrient Status in Children Suffering From Anorexia Nervosa: A Cohort of 349 Patients in a Referral Center for Eating Disorders.The International journal of eating disorders · 2026Article
- Selenoprotein S and the Causal Risk of Hypertension in Pregnancy: A Mendelian Randomization Study.Healthcare (Basel, Switzerland) · 2025Article
- Selenium and Arsenic Levels, Prevalence of Common Variants of Genes Involved in Their Metabolism, and Psoriasis Disease.Biomedicines · 2024Article
- Genetic and Environmental Factors in Autoimmune Thyroid Disease: Exploring Associations with Selenium Levels and Novel Loci in a Latvian Cohort.Current issues in molecular biology · 2024Article
- The regulation of methylation on the Z chromosome and the identification of multiple novel Male Hyper-Methylated regions in the chicken.PLoS genetics · 2024Article
- Metabolism and Anticancer Mechanisms of Selocompounds: Comprehensive Review.Biological trace element research · 2023Review
- Article
- Associations between Circulating SELENOP Level and Disorders of Glucose and Lipid Metabolism: A Meta-Analysis.Antioxidants (Basel, Switzerland) · 2022Review
- Article
- The Association of Familial Hypertension and Risk of Gestational Hypertension and Preeclampsia.International journal of environmental research and public health · 2021Article
- Fetal Programming Is Deeply Related to Maternal Selenium Status and Oxidative Balance; Experimental Offspring Health Repercussions.Nutrients · 2021Review
- The Prevalence of Inorganic Mercury in Human Kidneys Suggests a Role for Toxic Metals in Essential Hypertension.Toxics · 2021Article
- Supranutritional selenium suppresses ROS-induced generation of RANKL-expressing osteoclastogenic CD4Clinical & translational immunology · 2021Article
- Evaluating the Diagnostic Value of a Combined Indicator of Vitamin BFrontiers in nutrition · 2021Article
- Minerals in Pregnancy and Their Impact on Child Growth and Development.Molecules (Basel, Switzerland) · 2020Review
- First Trimester Microelements and their Relationships with Pregnancy Outcomes and Complications.Nutrients · 2020Article
- Serum Microelements in Early Pregnancy and their Risk of Large-for-Gestational Age Birth Weight.Nutrients · 2020Article
- Pregnancy, thyroid, and the potential use of selenium.Hormones (Athens, Greece) · 2020Review
- Selenium and at-risk pregnancy: challenges and controversies.Thyroid research · 2020Review
- Concentrations of toxic metals and essential trace elements vary among individual neurons in the human locus ceruleus.PloS one · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundLow selenium status in pregnancy has been associated with a number of adverse conditions. In nonpregnant populations, the selenium status or response to supplementation has been associated with polymorphisms in dimethylglycine dehydrogenase (DMGDH), selenoprotein P (SEPP1) and the glutathione peroxidases [cytosolic glutathione peroxidase (GPx1) and phospholipid glutathione peroxidase (GPx4)].
objectiveWe hypothesized that, in pregnant women, these candidate polymorphisms would be associated with selenium status in early pregnancy, its longitudinal change, and the interindividual response to selenium supplementation at 60 μg/d.
designWith the use of stored samples and data from the United Kingdom Selenium in Pregnancy Intervention (SPRINT) study in 227 pregnant women, we carried out genetic-association studies, testing for associations between selenium status, its longitudinal change, and response to supplementation and common genetic variation in DMGDH (rs921943), SEPP1 (rs3877899 and rs7579), GPx1 (rs1050450) and GPx4 (rs713041). Selenium status was represented by the concentration of whole-blood selenium at 12 and 35 wk of gestation, the concentration of toenail selenium at 16 wk of gestation, and plasma glutathione peroxidase (GPx3) activity at 12 and 35 wk of gestation.
resultsOur results showed that DMGDH rs921943 was significantly associated with the whole-blood selenium concentration at 12 wk of gestation (P = 0.032), which explained ≤2.0% of the variance. This association was replicated with the use of toenail selenium (P = 0.043). In unsupplemented women, SEPP1 rs3877899 was significantly associated with the percentage change in whole-blood selenium from 12 to 35 wk of gestation (P = 0.005), which explained 8% of the variance. In supplemented women, SEPP1 rs3877899 was significantly associated with the percentage change in GPx3 activity from 12 to 35 wk of gestation (P = 0.01), which explained 5.3% of the variance. Selenium status was not associated with GPx1, GPx4, or SEPP1 rs7579.
conclusionsIn agreement with previous studies, we show that the genetic variant rs921943 in DMGDH is significantly associated with selenium status in United Kingdom pregnant women. Notably, our study shows that women who carry the SEPP1 rs3877899 A allele are better able to maintain selenium status during pregnancy, and their GPx3 activity increases more with supplementation, which suggests better protection from low selenium status. The SPRINT study was registered at www.isrctn.com as ISRCTN37927591.
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