Evidence map›Paper›PMID 26675645›Full record

ArticleDementia and geriatric cognitive disorders extra

Alterations of the Neuroinflammatory Markers IL-6 and TRAIL in Alzheimer's Disease.

Ya-Ying Wu, Jung-Lung Hsu, Han-Cheng Wang, Shyh-Jong Wu, Chen-Jee Hong, Irene Han-Juo Cheng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The clinical correlation of proinflammatory and anti-inflammatory biomarkers with Alzheimer disease: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
  4. Trial
  5. Circulating Dkk1 and TRAIL Are Associated With Cognitive Decline in Community-Dwelling, Older Adults With Cognitive Concerns.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018
    Trial
  6. Article
  7. Article
  8. Review
  9. Article
  10. CD28BMC neurology · 2025
    Article
  11. Review
  12. Review
  13. Article
  14. Biofluid biomarkers for Alzheimer's disease.Frontiers in aging neuroscience · 2024
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Ya-Ying WuDepartment of Neurology, Show-Chwan Memorial Hospital, Chunghua, Taipei ; Institute of Brain Science, National Yang-Ming University, Taipei.
Jung-Lung HsuSection of Dementia and Cognitive Impairment, Department of Neurology, Chang Gung Memorial Hospital, Linkou, Taipei ; Graduate Institute of Humanities in Medicine, Taipei Medical University, Taipei ; Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei.
Han-Cheng WangDepartment of Neurology, Shin-Kong WHS Memorial Hospital, Taipei ; College of Medicine, Taipei Medical University, Taipei.
Shyh-Jong WuDepartment of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chen-Jee HongDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan ; Division of Psychiatry, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Irene Han-Juo ChengInstitute of Brain Science, National Yang-Ming University, Taipei ; Infection and Immunity Research Center, National Yang-Ming University, Taipei, Taiwan ; Brain Research Center, National Yang-Ming University, Taipei, Taiwan.
National Yang Ming Chiao Tung University · TWKaohsiung Medical University · TWShin Kong WHS Memorial Hospital · TWTaipei Medical University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to identify biomarkers of Alzheimer's disease (AD) in order to improve diagnostic accuracy at mild stage.

methodsAD patients aged >50 years were included in the disease group. We evaluated the relationship between potential blood and cerebrospinal fluid inflammatory biomarkers, cognitive status, temporal lobe atrophy and disease severity. Inflammatory biomarkers including interleukin 6 (IL-6), IL-18, fractalkine and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) levels were measured. APOE genotypes were determined.

resultsWe enrolled 41 subjects in the disease group and 40 subjects in the normal control group. The majority (88.9%) of subjects in the disease group had mild AD. Elevated levels of plasma IL-6 and decreased levels of plasma TRAIL in the disease group were noted. Plasma levels of IL-6 and TRAIL were significantly correlated with their cerebrospinal fluid levels.

conclusionPlasma IL-6 and TRAIL were identified as potential biomarkers of AD at an early stage.

Indexed as

Alzheimer's diseaseBiomarkerIL-6NeuroinflammationTRAIL

Identifiers

PMID26675645
PMCPMC4677720
OpenAlexW2198707617

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.