ArticleBMC infectious diseases2015
The prevalence and impact of antimicrobial allergies and adverse drug reactions at an Australian tertiary centre.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 79 citations in OpenAlex.
- Pharmacogenomics of antibacterial and antiviral therapies: Clinical actionability, evidence gaps, and future directions.Pharmacological reviews · 2026Review
- Clinical application of benzathine penicillin G as secondary prophylaxis and vaccines for patients with acute rheumatic fever and rheumatic heart disease: A comprehensive review.International journal of cardiology. Congenital heart disease · 2026Review
- Penicillin Allergy, Really?-A Cross-Sectional Mixed-Methods Study in Baden-Württemberg, Germany, to Explore General Practitioner Perspectives on Delabeling Potential in Primary Care.Antibiotics (Basel, Switzerland) · 2026Article
- HLA-A*02:01 Presents Penicillin-Modified Cysteinylated Peptides for T Cell Recognition.Allergy · 2025Article
- Article
- Penicillin allergy as an instrumental variable for estimating antibiotic effects on resistance.Nature communications · 2025Article
- Self-reported beta-lactam allergy, mislabeling and inappropriate antibiotic use: a study from South India.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Developing and disseminating an electronic penicillin allergy de-labelling tool using the model for improvement framework.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024Article
- [Precision medicine in infectious diseases].Innere Medizin (Heidelberg, Germany) · 2024Review
- Impact of penicillin allergy records on antimicrobial prescribing in hospitalised patients.Clinical medicine (London, England) · 2024Article
- Impact of antibiotic allergy labels on timely and appropriate antibiotics for sepsis in the emergency department.JAC-antimicrobial resistance · 2023Article
- Delabeling, safety, and impact of β-lactam allergy testing: A systematic review.The journal of allergy and clinical immunology. Global · 2023Article
- Penicillin de-labelling in vancouver, British Columbia, Canada: comparison of approaches, outcomes and future directions.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Study protocol for PREPARE: a phase II feasibility/safety randomised controlled trial on PeRiopErative Penicillin AlleRgy TEsting.BMJ open · 2023Article
- Standardized testing and written communication improve patient understanding of beta-lactam allergy testing outcomes: A multicenter, prospective study.The journal of allergy and clinical immunology. Global · 2022Article
- Impact of Fungal Spores on Asthma Prevalence and Hospitalization.International journal of molecular sciences · 2022Review
- Focus group study exploring the issues and the solutions to incorrect penicillin allergy-labelled patients: an antibiotic stewardship patient safety initiative.European journal of hospital pharmacy : science and practice · 2021Article
- Genetic diversity of group A rotavirus in acute gastroenteritis outpatients in Shanghai from 2017 to 2018.BMC infectious diseases · 2020Article
- The challenge of de-labeling penicillin allergy.Allergy · 2020Review
- A UK hospital survey to explore healthcare professional views and attitudes to patients incorrectly labelled as penicillin allergic: an antibiotic stewardship patient safety project.European journal of hospital pharmacy : science and practice · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence and impact of antimicrobial "allergy" labels and Adverse Drug Reactions (ADRs) on antibiotic usage and antimicrobial stewardship initiatives is ill defined. We sought to examine the rate of antimicrobial "allergy labels" at our tertiary referral centre and impacts on antimicrobial usage and appropriateness.
methodsTwo inpatient antimicrobial prevalence surveys were conducted over a 1-week period in November 2013 and 2014 as part of the prospective National Antimicrobial Prescribing Survey (NAPS). Post survey, patients recorded in the NAPS database were assigned to two groups based upon recorded antimicrobial "allergy label" and ADR: (i) Antimicrobial Allergy/ADR (AA) or (ii) No Antimicrobial Allergy/ADR (NAA). Antimicrobial usage and antimicrobial appropriateness were compared between AA and NAA groups.
resultsFrom 509 identified patients the prevalence of an antimicrobial allergy or ADR was 25 %. The prevalence of "allergy labels"/ADR was 10 % (51/509) for penicillin V/G, 5 % (24/509) cephalosporins, 4 % (22/509) trimethroprim-sulfamethoxazole and 3 % (17/509) aminopenicillins. One thousand and seventy antimicrobials were prescribed during the study periods, the median antimicrobial duration was longer in the AA versus NAA group (6 days vs. 4 days; p = 0.018), and proportion of inappropriate antimicrobial prescribing higher in the AA group compared with NAA (29 %; 35/120 vs. 23 %; 86/367, p = 0.22). Oral antimicrobial administration was higher in the NAA than AA group (60 %; 177/297 vs. 46 %; 356/793, p = 0.0001). The proportion of patients that received a β-lactam was lower in the AA versus NAA group (60 % vs. 79 %, p = 0.0001).
conclusionsIn an Australian tertiary referral centre an antimicrobial "allergy" or ADR label was found to significantly impacted on rate of oral antimicrobial administration, beta-lactam usage, antimicrobial duration and antimicrobial appropriateness.
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