Evidence map›Paper›PMID 26675566›Full record

ReviewJournal of cachexia, sarcopenia and muscle2015

Biomarkers for physical frailty and sarcopenia: state of the science and future developments.

Riccardo Calvani, Federico Marini, Matteo Cesari, Matteo Tosato, Stefan D Anker, Stephan von Haehling, Ram R Miller, Roberto Bernabei, Francesco Landi, Emanuele Marzetti and 1 more

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cachexia, sarcopenia and muscle, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07689994 (Evaluation of the Effect of a Seaweed Flour- and Leucine-Enriched Food on Metabolic and Inflammatory Status in Older Adults With Probable Sarcopenia or Sarcopenia), which is not on this map. Cited by 133 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07689994 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of the Effect of a Seaweed Flour- and Leucine-Enriched Food on Metabolic and Inflammatory Status in Older Adults With Probable Sarcopenia or Sarcopenia: A Prospective, Controlled, Randomized, Double-Blind, Three-Arm Parallel Clinical Trial

TypeinterventionalSponsorFinis Terrae UniversityRan2026 to 2027Enrolled102ConditionsSarcopenia in ElderlyArmsStandard chocolate-flavored cake, Leucine-Enriched Chocolate Cake, Leucine Plus Seaweed Flour-Enriched Chocolate Cake
3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Frailty in emergency surgery: expanding the role of biomarkers.Annals of the Royal College of Surgeons of England · 2026
    Article
  14. Observational
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Riccardo CalvaniDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart Rome, Italy.
Federico MariniDepartment of Chemistry, "Sapienza" University of Rome Rome, Italy.
Matteo CesariGérontopôle, Centre Hospitalier Universitaire de Toulouse Toulouse, France ; Institut national de la santé et de la recherche médicale (UMR1027), Université de Toulouse III Paul Sabatier Toulouse, France.
Matteo TosatoDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart Rome, Italy.
Stefan D AnkerDepartment of Innovative Clinical Trials, University Medical Center Göttingen (UMG) Göttingen, Germany.
Stephan von HaehlingDepartment of Innovative Clinical Trials, University Medical Center Göttingen (UMG) Göttingen, Germany.
Ram R MillerMuscle Metabolism Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapeutic Area, GlaxoSmithKline R&D Research Triangle Park, NC, USA.
Roberto BernabeiDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart Rome, Italy.
Francesco LandiDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart Rome, Italy.
Emanuele MarzettiDepartment of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart Rome, Italy.
SPRINTT consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Physical frailty and sarcopenia are two common and largely overlapping geriatric conditions upstream of the disabling cascade. The lack of a unique operational definition for physical frailty and sarcopenia and the complex underlying pathophysiology make the development of biomarkers for these conditions extremely challenging. Indeed, the current definitional ambiguities of physical frailty and sarcopenia, together with their heterogeneous clinical manifestations, impact the accuracy, specificity, and sensitivity of individual biomarkers proposed so far. In this review, the current state of the art in the development of biomarkers for physical frailty and sarcopenia is presented. A novel approach for biomarker identification and validation is also introduced that moves from the 'one fits all' paradigm to a multivariate methodology.

Indexed as

AgeingCirculating markersDisabilityImagingMultivariate modellingPhysical performance

Identifiers

PMID26675566
PMCPMC4670735

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.