ArticlePloS one2015
Increased Frontal Response May Underlie Decreased Tinnitus Severity.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Modulated Alpha Power as a Predictor of Tinnitus Alleviation.The journal of international advanced otology · 2024Trial
- Differential brain responses to affective sounds in misophonia and hyperacusis: A task-based fMRI approach.Cognitive, affective & behavioral neuroscience · 2026Article
- Tinnitus and tinnitus disorder: Genetic, neurobiological, and clinical differentiation.iScience · 2026Review
- Perceptual and neural biomarkers of distraction from an external sound source are not associated with tinnitus severity.bioRxiv : the preprint server for biology · 2026Article
- Review and Perspective on Brain Bases of Tinnitus.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Current and Emerging Therapies for Chronic Subjective Tinnitus.Journal of clinical medicine · 2023Review
- Down-Regulation of Tinnitus Negative Valence via Concurrent HD-tDCS and PEI Technique: A Pilot Study.Brain sciences · 2023Article
- Disruptions of default mode network and precuneus connectivity associated with cognitive dysfunctions in tinnitus.Scientific reports · 2023Article
- Self-Directed Neurofeedback Treatment for Subjective Tinnitus Patients Evaluated by Multimodal Functional Imaging.Neural plasticity · 2022Article
- Decreased resting perfusion in precuneus and posterior cingulate cortex predicts tinnitus severity.Current research in neurobiology · 2021Article
- A Review and a Framework of Variables for Defining and Characterizing Tinnitus Subphenotypes.Brain sciences · 2020Review
- Tinnitus impairs segregation of competing speech in normal-hearing listeners.Scientific reports · 2020Article
- Effects of Chronic Tinnitus on Metabolic and Structural Changes in Subjects With Mild Cognitive Impairment.Frontiers in aging neuroscience · 2020Article
- Electrophysiological correlates of focused attention on low- and high-distressed tinnitus.PloS one · 2020Article
- The Role of Cognitive Control in Tinnitus and Its Relation to Speech-in-Noise Performance.Journal of audiology & otology · 2019Article
- Functional Brain Changes During Mindfulness-Based Cognitive Therapy Associated With Tinnitus Severity.Frontiers in neuroscience · 2019Article
- Chronic tinnitus and the limbic system: Reappraising brain structural effects of distress and affective symptoms.NeuroImage. Clinical · 2019Article
- Dissociating tinnitus patients from healthy controls using resting-state cyclicity analysis and clustering.Network neuroscience (Cambridge, Mass.) · 2019Article
- MRI Verification of a 10-20 Targeting Protocol Used During Transcranial Magnetic Stimulation Sessions for Tinnitus.Brain topography · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe overall goal of the study was to identify functional and behavioral differences between individuals with higher tinnitus distress and individuals with lower tinnitus distress. Subsequent exploratory analyses were conducted to investigate the role physical activity may have on the observed results between high and low distress groups. The purpose of the experiment was to identify brain regions to be targeted in future intervention studies for tinnitus.
designA total of 32 individuals with varying levels of tinnitus severity were recruited from the Urbana-Champaign area. Volunteers were divided into higher tinnitus distress (HD) and lower tinnitus distress (LD) groups. Note that these groups also significantly differed based on physical activity level and were subsequently stratified into higher and lower physical activity level subgroups for exploratory analysis. While in a functional magnetic resonance imaging (fMRI) scanner, subjects listened to affective sounds classified as pleasant, neutral or unpleasant from the International Affective Digital Sounds database.
resultsThe HD group recruited amygdala and parahippocampus to a greater extent than the LD group when listening to affective sounds. The LD group engaged frontal regions to a greater extent when listening to the affective stimuli compared to the HD group. Both higher physical activity level subgroups recruited more frontal regions, and both lower levels of physical activity subgroups recruited more limbic regions respectively.
conclusionIndividuals with lower tinnitus distress may utilize frontal regions to better control their emotional response to affective sounds. Our analysis also suggests physical activity may contribute to lower tinnitus severity and greater engagement of the frontal cortices. We suggest that future intervention studies focus on changes in the function of limbic and frontal regions when evaluating the efficacy of treatment. Additionally, we recommend further investigation concerning the impact of physical activity level on tinnitus distress.
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