Evidence map›Paper›PMID 26675254›Full record

ArticleJournal of the American Heart Association2015

Left Atrial Inexcitability in Children With Congenital Lupus-Induced Complete Atrioventricular Block.

Sylvia Abadir, Anne Fournier, Suzanne J Vobecky, Charles V Rohlicek, Philippe Romeo, Paul Khairy

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Sylvia AbadirDivisions of Cardiology and Cardiac Surgery, CHU mère-enfant Sainte-Justine, Université de Montréal, Quebec, Canada (S.A., A.F., S.J.V., P.K.) Department of Cardiology, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada (S.A., C.V.R.).
Anne FournierDivisions of Cardiology and Cardiac Surgery, CHU mère-enfant Sainte-Justine, Université de Montréal, Quebec, Canada (S.A., A.F., S.J.V., P.K.).
Suzanne J VobeckyDivisions of Cardiology and Cardiac Surgery, CHU mère-enfant Sainte-Justine, Université de Montréal, Quebec, Canada (S.A., A.F., S.J.V., P.K.).
Charles V RohlicekDepartment of Cardiology, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada (S.A., C.V.R.).
Philippe RomeoDepartment of Medicine and Pathology, Montreal Heart Institute, Université de Montréal, Québec, Canada (P.R., P.K.).
Paul KhairyDivisions of Cardiology and Cardiac Surgery, CHU mère-enfant Sainte-Justine, Université de Montréal, Quebec, Canada (S.A., A.F., S.J.V., P.K.) Department of Medicine and Pathology, Montreal Heart Institute, Université de Montréal, Québec, Canada (P.R., P.K.).
Centre Hospitalier Universitaire Sainte-Justine · CAMontreal Children's Hospital · CAMontreal Heart Institute · CAUniversité de Montréal · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCongenital atrioventricular block is a well-established immunologic complication of maternal systemic lupus erythematosus. We sought to further characterize the electrophysiological manifestations of maternal systemic lupus erythematosus on neonatal atria. METHODS AND

resultsCases of isolated congenital atrioventricular block treated at our center over the past 41 years were identified. Data were extracted from clinical charts, pacemaker interrogations, ECGs, echocardiograms, and histopathological reports, when available. Of 31 patients with isolated congenital atrioventricular block, 18 were negative for maternal antibodies and had normal epicardial atrial sensing and pacing thresholds. In contrast, 12 of 13 patients with positive maternal antibodies had epicardial pacemakers, 5 (42%) of whom had left atrial (LA) inexcitability and/or atrial conduction delay. In 3 patients, the LA could not be captured despite high-output pacing. The fourth patient had acutely successful LA appendage and left ventricular lead placement. At early follow-up, an increased delay between the surface P-wave and intracardiac atrial depolarization was observed, indicative of atrial conduction delay. The fifth patient exhibited LA lead dysfunction, with atrial under-sensing and an increased capture threshold, 2 weeks after implantation. Biopsies of LA appendages performed in 2 patients showed no evidence of atrial fibrosis or loss of atrial myocytes.

conclusionsHerein, we report previously undescribed yet prevalent electrophysiological ramifications of maternal systemic lupus erythematosus, which extend beyond congenital atrioventricular block to encompass alterations in LA conduction, including LA inexcitability. These manifestations can complicate epicardial pacemaker implantation in newborns. In the absence of histological evidence of extensive atrial fibrosis, immune-mediated functional impairment of electrical activity is suspected.

Indexed as

Atrial Function, LeftAtrioventricular BlockChildChild, PreschoolEchocardiographyElectrocardiographyFemaleHeart AtriaHumansInfantInfant, NewbornLupus Erythematosus, SystemicMalePacemaker, ArtificialPregnancyPregnancy Complicationsatrial inexcitabilityatrioventricular blockcongenitalinteratrial blockmaternal lupus

Identifiers

PMID26675254
PMCPMC4845288
OpenAlexW2207654948

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.