Evidence map›Paper›PMID 26675251›Full record

ArticleJournal of the American Heart Association2015

Relation Between Circulating Inflammatory Chemokines and Vascular Characteristics in Healthy, Young Children.

Anouk L M Eikendal, Annemieke M V Evelein, Cuno S P M Uiterwaal, Cornelis K van der Ent, Frank L J Visseren, Michiel L Bots, Imo E Hoefer, Hester M den Ruijter, Geertje W Dalmeijer

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Anouk L M EikendalDepartment of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands (A.M.E.).
Annemieke M V EveleinDepartment of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands (A.V.E., C.K.E.).
Cuno S P M UiterwaalJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (C.M.U., M.L.B., G.W.D.).
Cornelis K van der EntDepartment of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands (A.V.E., C.K.E.).
Frank L J VisserenDepartment of Vascular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands (F.J.V.).
Michiel L BotsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (C.M.U., M.L.B., G.W.D.).
Imo E HoeferLaboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (I.E.H., H.M.R.).
Hester M den RuijterLaboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (I.E.H., H.M.R.).
Geertje W DalmeijerJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands (C.M.U., M.L.B., G.W.D.).
University Medical Center Utrecht · NLWilhelmina Children's Hospital · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtherosclerosis begins in childhood with the occurrence of inflammatory vascular wall alterations that are detectable with B-mode ultrasound. Chemokines appear to be involved in the development of these alterations given that they occur early in the atherosclerotic pathway as mediators of vascular inflammation. However, this has not extensively been investigated. Therefore, we studied in healthy young children whether chemokines monocyte chemotactic protein 1 (MCP-1), regulated on activation normal T-cell expressed and secreted (RANTES), and vascular and intercellular adhesion molecules (VCAM and ICAM) related to vascular characteristics of the carotid artery. METHODS AND

resultsWe obtained demography, anthropometry, and overnight fasting plasma of 139 eight-year-old children of the Wheezing Illnesses Study Leidsche Rijn birth cohort. Carotid intima-media thickness (CIMT), distensibility, and Young's Elastic Modulus (YEM) of the common carotid artery were measured sonographically. Chemokine plasma levels were assessed using a multiplex assay. We studied the relation between the chemokines and vascular characteristics using multivariable linear regression analyses with adjustments for sex, systolic blood pressure, homeostasis model assessment of insulin resistance, triglycerides, low-density lipoprotein- and high-density lipoprotein-cholesterol. Of the studied chemokines, RANTES related to common carotid distensibility and YEM. One standard deviation increase in RANTES level related to a 5.45-MPA(-1) (95% confidence interval [CI], -9.43, -1.39; P=0.01) decrease in distensibility and to a 5.55-kPa increase in YEM (95% CI, 0.40, 10.85; P=0.03). RANTES did not relate to CIMT. MCP-1, VCAM, and ICAM did not relate to any of the studied vascular characteristics.

conclusionRANTES appears to be involved in the development of preatherosclerotic inflammatory vascular alterations already in healthy, young children. This may provide further insight into the early-life origins of atherosclerosis.

Indexed as

AtherosclerosisBlood PressureCarotid Artery, CommonCarotid Intima-Media ThicknessCell Adhesion MoleculesChemokine CCL2Chemokine CCL5ChemokinesChildFemaleHumansInsulin ResistanceLipoproteins, HDLLipoproteins, LDLMaleTriglyceridesCCL2 protein, humanCell Adhesion MoleculesChemokine CCL2Chemokine CCL5ChemokinesLipoproteins, HDLLipoproteins, LDLTriglyceridesVascular Cell Adhesion Molecule-1arteriosclerosisinflammationpediatricsrisk factorsultrasonography

Identifiers

PMID26675251
PMCPMC4845277
OpenAlexW2260504890

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.