ArticleThe EMBO journal2016
Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification.
Article in The EMBO journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Trial
- The exploration of immunological landscape and drug targets in chronic rhinosinusitis with nasal polyps.The World Allergy Organization journal · 2026Article
- The role of MAPK, notch and Wnt signaling pathways in papillary thyroid cancer: Evidence from a systematic review and meta-analyzing microarray datasets employing bioinformatics knowledge and literature.Biochemistry and biophysics reports · 2024Article
- Distinctive Expression of MetastamiRs in Breast Cancer Mesenchymal Stem Cells Isolated from Solid Tumor.Current stem cell research & therapy · 2024Article
- Article
- The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency.Nature communications · 2023Article
- Rapid and robust directed differentiation of mouse epiblast stem cells into definitive endoderm and forebrain organoids.Development (Cambridge, England) · 2022Article
- Efficient hepatic differentiation and regeneration potential under xeno-free conditions using mass-producible amnion-derived mesenchymal stem cells.Stem cell research & therapy · 2021Article
- C644-0303, a small-molecule inhibitor of the Wnt/β-catenin pathway, suppresses colorectal cancer growth.Cancer science · 2021Article
- Establishment of Mouse Primed Stem Cells by Combination of Activin and LIF Signaling.Frontiers in cell and developmental biology · 2021Article
- Whsc1 links pluripotency exit with mesendoderm specification.Nature cell biology · 2019Article
- TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer.Acta biochimica et biophysica Sinica · 2019Article
- Negative feedback via RSK modulates Erk-dependent progression from naïve pluripotency.EMBO reports · 2018Article
- Rare variants in SOX17 are associated with pulmonary arterial hypertension with congenital heart disease.Genome medicine · 2018Article
- TCF7L1 suppresses primitive streak gene expression to support human embryonic stem cell pluripotency.Development (Cambridge, England) · 2018Article
- The Wnt Transcriptional Switch: TLE Removal or Inactivation?BioEssays : news and reviews in molecular, cellular and developmental biology · 2018Review
- NODAL Secures Pluripotency upon Embryonic Stem Cell Progression from the Ground State.Stem cell reports · 2017Article
- Activation of Wnt/β-catenin signalling via GSK3 inhibitors direct differentiation of human adipose stem cells into functional hepatocytes.Scientific reports · 2017Article
- Wnt target genes and where to find them.F1000Research · 2017Review
- Gene expression and pathway analysis ofWorld journal of stem cells · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
The molecular machinery that directs formation of definitive endoderm from pluripotent stem cells is not well understood. Wnt/β-catenin and Nodal signalling have been implicated, but the requirements for lineage specification remain incompletely defined. Here, we demonstrate a potent effect of inhibiting glycogen synthase kinase 3 (GSK3) on definitive endoderm production. We find that downstream of GSK3 inhibition, elevated cMyc and β-catenin act in parallel to reduce transcription and DNA binding, respectively, of the transcriptional repressor Tcf7l1. Tcf7l1 represses FoxA2, a pioneer factor for endoderm specification. Deletion of Tcf7l1 is sufficient to allow upregulation of FoxA2 in the presence of Activin. In wild-type cells, cMyc contributes by reducing Tcf7l1 mRNA, while β-catenin acts on Tcf7l1 protein. GSK3 inhibition is further required for consolidation of endodermal fate via upregulation of Sox17, highlighting sequential roles for Wnt signalling. The identification of a cMyc/β-catenin-Tcf7l1-FoxA2 axis reveals a de-repression mechanism underlying endoderm induction that may be recapitulated in other developmental and patho-logical contexts.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.