ArticleJournal of Crohn's & colitis2016
Diagnosis of Helicobacter Pylori Infection is Associated with Lower Prevalence and Subsequent Incidence of Crohn's Disease.
Article in Journal of Crohn's & colitis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Association Between Infections and Risk of Ankylosing Spondylitis: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2021Pooled it
- Odoribacter splanchnicus-derived extracellular vesicles alleviate inflammatory bowel disease by modulating gastrointestinal inflammation and intestinal barrier function via the NLRP3 inflammasome suppression.Molecular medicine (Cambridge, Mass.) · 2025Article
- Bibliometric analysis of the correlation between H. pylori and inflammatory bowel disease.JGH open : an open access journal of gastroenterology and hepatology · 2024Review
- Environmental and Genetic Determinants of Ankylosing Spondylitis.International journal of molecular sciences · 2024Review
- The first study appraising colonic diverticulosis and Helicobacter pylori diagnosed by histopathology.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Association between intestinal microbiota and inflammatory bowel disease.Animal models and experimental medicine · 2022Review
- Bile Acids and the Microbiome: Making Sense of This Dynamic Relationship in Their Role and Management in Crohn's Disease.Canadian journal of gastroenterology & hepatology · 2022Review
- Hot topics on fecal microbiota transplantation for the treatment of inflammatory bowel disease.Frontiers in medicine · 2022Review
- Upper gastrointestinal tract involvement of Crohn disease: clinical implications in children and adolescents.Clinical and experimental pediatrics · 2022Article
- Ginger Extract Decreases Susceptibility to Dextran Sulfate Sodium-Induced Colitis in Mice Following Early Antibiotic Exposure.Frontiers in medicine · 2021Article
- A positive Helicobacter pylori test is associated with low spondylarthritis incidence in a Danish historical cohort study.Rheumatology international · 2020Article
- Helicobacter pylori is Associated with Less Fistulizing, Stricturing, and Active Colitis in Crohn's Disease Patients.Cureus · 2019Article
- Repeated mild traumatic brain injury affects microbial diversity in rat jejunum.Journal of biosciences · 2019Article
- Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome.Pathogens (Basel, Switzerland) · 2019Review
- Genetic and Environmental Contributors for Celiac Disease.Current allergy and asthma reports · 2019Review
- The negative association between inflammatory bowel disease and Helicobacter pylori seropositivity.Caspian journal of internal medicine · 2019Article
- Association of Helicobacter pylori and Crohn's Disease Incidence: An Inversion Reaction?Digestive diseases and sciences · 2017Article
- Microbes and Viruses Are Bugging the Gut in Celiac Disease. Are They Friends or Foes?Frontiers in microbiology · 2017Review
- Making sense of the cause of Crohn's - a new look at an old disease.F1000Research · 2016Review
- Lower Incidence of Hepatobiliary Cancer inJournal of clinical and experimental hepatologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsHelicobacter pylori infection may protect against some chronic inflammatory diseases. This study examined H. pylori infection and its association with the prevalence of the gastrointestinal diseases Crohn's disease [CD], ulcerative colitis [UC], and coeliac disease [CeD]. Incident cases in a follow-up period after H. pylori testing were recorded to investigate if protective effects of H. pylori persisted after probable eradication.
methodsThis was a historical cohort study performed in the Central Denmark Region. Patients were enrolled consecutively from primary health care centres after a urea breath test [UBT] for H. pylori and were then followed for a median of 6 years. The patient's diseases, country of birth, and gender were acquired from nationwide administrative registries. We used logistic regression to compare the prevalences of CD, UC, and CeD and Cox regression to compare the incidences of CD, UC, and CeD between H. pylori-positive and H. pylori-negative patients, adjusting for confounding variables.
resultsWe found a lower prevalence of CD in H. pylori-positive than in H. pylori-negative patients (odds ratio = 0.36 [0.17-0.75]). There were fewer incident cases of CD in H. pylori-positive than H. pylori-negative patients in the follow-up period (hazard ratio = 0.59 [0.36-0.96]). Similar trends were found for CeD but not for UC.
conclusionsH. pylori infection may be a protective factor against the development of CD. However, the incidence of CD is still reduced after UBT and probable H. pylori eradication; thus, H. pylori status may be a marker for other factors that protect against CD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.