ArticleProceedings. Biological sciences2015
Interactions among bacterial strains and fluke genotypes shape virulence of co-infection.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Coinfections Dampen the Effects of Temperature on Host-Parasite Interactions.Ecology letters · 2026Article
- Counterproductive: coinfection of a water flea by a fungus and a microsporidium reduces the reproductive outputs of all parties.Scientific reports · 2026Article
- Review
- The Dominance of Coinfecting Parasites' Indirect Genetic Effects on Host Traits.The American naturalist · 2024Article
- Microsporidian coinfection reduces fitness of a fungal pathogen due to rapid host mortality.mBio · 2024Article
- Genomic variation in Plasmodium relictum (lineage SGS1) and its implications for avian malaria infection outcomes: insights from experimental infections and genome-wide analysis.Malaria journal · 2024Article
- How infection-triggered pathobionts influence virulence evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Increased virulence due to multiple infection inParasitology · 2024Article
- Coinfection with a virus constrains within-host infection load but increases transmission potential of a highly virulent fungal plant pathogen.Ecology and evolution · 2022Article
- Glochidial infection by the endangered Margaritifera margaritifera (Mollusca) increased survival of salmonid host (Pisces) during experimental Flavobacterium disease outbreak.Parasitology research · 2021Article
- Variation in parasite resistance of Arctic charr,Ecology and evolution · 2021Article
- Comparison of Delivery Methods in Phage Therapy againstAntibiotics (Basel, Switzerland) · 2021Article
- Dual RNAseq highlights the kinetics of skin microbiome and fish host responsiveness to bacterial infection.Animal microbiome · 2021Article
- Quantity and Quality of Aquaculture Enrichments Influence Disease Epidemics and Provide Ecological Alternatives to Antibiotics.Antibiotics (Basel, Switzerland) · 2021Article
- Coinfecting parasites can modify fluctuating selection dynamics in host-parasite coevolution.Ecology and evolution · 2020Article
- Sequential infection can decrease virulence in a fish-bacterium-fluke interaction: Implications for aquaculture disease management.Evolutionary applications · 2019Article
- Minor environmental concentrations of antibiotics can modify bacterial virulence in co-infection with a non-targeted parasite.Biology letters · 2018Article
- Spatiotemporal and gender-specific parasitism in two species of gobiid fish.Ecology and evolution · 2018Article
- Pathogenic endoparasites of the spotted seatrout, Cynoscion nebulosus: patterns of infection in estuaries of South Carolina, USA.Parasitology research · 2017Article
- Application of high resolution melting assay (HRM) to study temperature-dependent intraspecific competition in a pathogenic bacterium.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most studies of virulence of infection focus on pairwise host-parasite interactions. However, hosts are almost universally co-infected by several parasite strains and/or genotypes of the same or different species. While theory predicts that co-infection favours more virulent parasite genotypes through intensified competition for host resources, knowledge of the effects of genotype by genotype (G × G) interactions between unrelated parasite species on virulence of co-infection is limited. Here, we tested such a relationship by challenging rainbow trout with replicated bacterial strains and fluke genotypes both singly and in all possible pairwise combinations. We found that virulence (host mortality) was higher in co-infections compared with single infections. Importantly, we also found that the overall virulence was dependent on the genetic identity of the co-infecting partners so that the outcome of co-infection could not be predicted from the respective virulence of single infections. Our results imply that G × G interactions among co-infecting parasites may significantly affect host health, add to variance in parasite fitness and thus influence evolutionary dynamics and ecology of disease in unexpected ways.
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