ArticleJournal of the American Chemical Society2016
Enantioselective Rh-Catalyzed Carboacylation of C═N Bonds via C-C Activation of Benzocyclobutenones.
Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Catalytic asymmetric intermolecular [4 + 2] annulation of benzocyclobutenones with Alkynes and activated carbonyls via C-C activation.Nature communications · 2025Article
- Ring Expansion via Palladium-Catalyzed Aryne Insertion into C-C Bonds of Benzocyclobutenones.Angewandte Chemie (International ed. in English) · 2025Article
- Aza-[4 + 2]-cycloaddition of benzocyclobutenones into isoquinolinone derivatives enabled by photoinduced regio-specific C-C bond cleavage.Nature communications · 2024Article
- Catalytic [4+2]- and [4+4]-cycloaddition using furan-fused cyclobutanone as a privileged C4 synthon.Nature communications · 2024Article
- Deconstructive Synthesis of Bridged and Fused Rings via Transition-Metal-Catalyzed "Cut-and-Sew" Reactions of Benzocyclobutenones and Cyclobutanones.Accounts of chemical research · 2022Article
- An endo-Directing-Group Strategy Unlocks Enantioselective (3+1+2) Carbonylative Cycloadditions of Aminocyclopropanes.Angewandte Chemie (International ed. in English) · 2022Article
- Catalytic Enantioselective Synthesis of γ-Lactams with β-Quaternary Centers via Merging of C-C Activation and Sulfonyl Radical Migration.Journal of the American Chemical Society · 2022Article
- Nickel-Catalyzed Asymmetric Domino Ring Opening/Cross-Coupling Reaction of Cyclobutanones via a Reductive Strategy.iScience · 2020Article
- Enantioselective cyanation via radical-mediated C-C single bond cleavage for synthesis of chiral dinitriles.Nature communications · 2019Article
- Kinetic Resolution via Rh-Catalyzed C-C Activation of Cyclobutanones at Room Temperature.Journal of the American Chemical Society · 2019Article
- Catalytic Ring Expansions of Cyclic Alcohols Enabled by Proton-Coupled Electron Transfer.Journal of the American Chemical Society · 2019Article
- Concise Synthesis of (-)-Cycloclavine and (-)-5- epi-Cycloclavine via Asymmetric C-C Activation.Journal of the American Chemical Society · 2018Article
- Fused-Ring Formation by an Intramolecular "Cut-and-Sew" Reaction between Cyclobutanones and Alkynes.Angewandte Chemie (International ed. in English) · 2018Article
- Cobalt-Catalyzed Intramolecular Alkyne/Benzocyclobutenone Coupling: C-C Bond Cleavage via a Tetrahedral Dicobalt Intermediate.ACS catalysis · 2018Article
- "Cut and Sew" Transformations via Transition-Metal-Catalyzed Carbon-Carbon Bond Activation.ACS catalysis · 2017Article
- Cyclobutenones and Benzocyclobutenones: Versatile Synthons in Organic Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2016Review
- Nickel-Catalyzed Chemo- and Enantioselective Coupling between Cyclobutanones and Allenes: Rapid Synthesis of [3.2.2] Bicycles.Angewandte Chemie (International ed. in English) · 2016Article
- Synthesis and applications of rhodacyclopentanones derived from C-C bond activation.Chemical communications (Cambridge, England) · 2016Article
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4 authors.
Funding
Abstract
Herein we describe the first enantioselective Rh-catalyzed carboacylation of oximes (imines) via C-C activation. In this transformation, the benzocyclobutenone C1-C2 bond is selectively activated by a low valent rhodium catalyst and subsequently the resulting two Rh-C bonds add across a C═N bond, which provides a unique approach to access chiral lactams. A range of polycyclic nitrogen-containing scaffolds were obtained in good yields with excellent enantioselectivity. Further derivatization of the lactam products led to a rapid entry to various novel fused heterocycles.
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