Evidence map›Paper›PMID 26674848›Full record

ReviewWorld journal of diabetes2015

Skeletal muscle as a therapeutic target for delaying type 1 diabetic complications.

Samantha K Coleman, Irena A Rebalka, Donna M D'Souza, Thomas J Hawke

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Samantha K ColemanSamantha K Coleman, Irena A Rebalka, Donna M D'Souza, Thomas J Hawke, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Irena A RebalkaSamantha K Coleman, Irena A Rebalka, Donna M D'Souza, Thomas J Hawke, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Donna M D'SouzaSamantha K Coleman, Irena A Rebalka, Donna M D'Souza, Thomas J Hawke, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
Thomas J HawkeSamantha K Coleman, Irena A Rebalka, Donna M D'Souza, Thomas J Hawke, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.
McMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease targeting the pancreatic beta-cells and rendering the person hypoinsulinemic and hyperglycemic. Despite exogenous insulin therapy, individuals with T1DM will invariably develop long-term complications such as blindness, kidney failure and cardiovascular disease. Though often overlooked, skeletal muscle is also adversely affected in T1DM, with both physical and metabolic derangements reported. As the largest metabolic organ in the body, impairments to skeletal muscle health in T1DM would impact insulin sensitivity, glucose/lipid disposal and basal metabolic rate and thus affect the ability of persons with T1DM to manage their disease. In this review, we discuss the impact of T1DM on skeletal muscle health with a particular focus on the proposed mechanisms involved. We then identify and discuss established and potential adjuvant therapies which, in association with insulin therapy, would improve the health of skeletal muscle in those with T1DM and thereby improve disease management- ultimately delaying the onset and severity of other long-term diabetic complications.

Indexed as

AdiponectinExerciseLeptinMetabolismMyostatinSkeletal muscleType 1 diabetes mellitus

Identifiers

PMID26674848
PMCPMC4673386
OpenAlexW2406649600

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.