ArticleBlood transfusion = Trasfusione del sangue2016
Deterioration of red blood cell mechanical properties is reduced in anaerobic storage.
Article in Blood transfusion = Trasfusione del sangue, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Metabolic alterations in erythrocytes associated with long-term hypoxia at high altitude.BMC genomics · 2025Article
- Human red blood cell ATP content and export under hypoxic and/or isocapnic storage conditions.Frontiers in physiology · 2025Article
- New and emerging technologies for pretransfusion blood quality assessment: A state-of-the-art review.Transfusion · 2024Review
- Hypoxically stored RBC resuscitation in a rat model of traumatic brain injury and severe hemorrhagic shock.Life sciences · 2024Article
- Atomic Force Microscopy and High-Resolution Spectrophotometry for Study of Anoxemia and Normoxemia in Model Experiment In Vitro.International journal of molecular sciences · 2023Article
- Cow blood - A superior storage option in forensics?Heliyon · 2023Article
- Deep ensemble learning enables highly accurate classification of stored red blood cell morphology.Scientific reports · 2023Article
- Intermittent scavenging of storage lesion from stored red blood cells by electrospun nanofibrous sheets enhances their quality and shelf-life.Nature communications · 2022Article
- Preclinical evaluation of the preservation of red blood cell concentrates by hypoxic storage technology for transfusion in sickle cell disease.Haematologica · 2022Article
- Effect of Hypoxic Blood Infusion on Pulmonary Physiology.Frontiers in physiology · 2022Review
- Do We Store Packed Red Blood Cells under "Quasi-Diabetic" Conditions?Biomolecules · 2021Review
- Non-invasive acquisition of mechanical properties of cells via passive microfluidic mechanisms: A review.Biomicrofluidics · 2021Review
- Microfluidic capillary networks are more sensitive than ektacytometry to the decline of red blood cell deformability induced by storage.Scientific reports · 2021Article
- Concurrent Assessment of Deformability and Adhesiveness of Sickle Red Blood Cells by Measuring Perfusion of an Adhesive Artificial Microvascular Network.Frontiers in physiology · 2021Article
- Dynamics of shape recovery by stored red blood cells during washing at the single cell level.Transfusion · 2020Article
- Development of a flow standard to enable highly reproducible measurements of deformability of stored red blood cells in a microfluidic device.Transfusion · 2020Article
- Transfusion of Anaerobically or Conventionally Stored Blood After Hemorrhagic Shock.Shock (Augusta, Ga.) · 2020Article
- Oxygen in Red Blood Cell Concentrates: Influence of Donors' Characteristics and Blood Processing.Frontiers in physiology · 2020Article
- Blood rheology biomarkers in sickle cell disease.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundHypothermic storage of red blood cells (RBCs) results in progressive deterioration of the rheological properties of the cells, which may reduce the efficacy of RBC transfusions. Recent studies have suggested that storing RBC units under anaerobic conditions may reduce this storage-induced deterioration. MATERIALS AND
methodsThe aim of this study was to compare the rheological properties of conventionally and anaerobically stored RBC and provide a measure of the relationship between oxidative damage to stored RBC and their ability to perfuse microvascular networks. Three different microfluidic devices were used to measure the ability of both types of stored RBC to perfuse artificial microvascular networks. Flow rates of the RBC passing through the entire network (bulk perfusion) and the individual capillaries (capillary perfusion) of the devices were measured on days 2, 21, 42, and 63 of storage.
resultsThe bulk perfusion rates for anaerobically stored RBC were significantly higher than for conventionally stored RBCs over the entire duration of storage for all devices (up to 10% on day 42; up to 14% on day 63). Capillary perfusion rates suggested that anaerobically stored RBC units contained significantly fewer non-deformable RBC capable of transiently plugging microfluidic device capillaries. The number of plugging events caused by these non-deformable RBC increased over the 63 days of hypothermic storage by nearly 16- to 21-fold for conventionally stored units, and by only about 3- to 6-fold for anaerobically stored units. DISCUSSION: The perfusion measurements suggest that anaerobically stored RBC retain a greater ability to perfuse networks of artificial capillaries compared to conventionally (aerobically) stored RBC. It is likely that anaerobic storage confers this positive effect on the bulk mechanical properties of stored RBC by significantly reducing the number of non-deformable cells present in the overall population of relatively well-preserved RBC.
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