ArticleBlood transfusion = Trasfusione del sangue2016
A fast-track anaemia clinic in the Emergency Department: feasibility and efficacy of intravenous iron administration for treating sub-acute iron deficiency anaemia.
Article in Blood transfusion = Trasfusione del sangue, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05304442 (Intravenous Ferric Derisomaltose for Moderate to Severe Anemia Due to Uterine Bleeding in the Emergency Department), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intravenous Ferric Derisomaltose for Moderate to Severe Anemia Due to Uterine Bleeding in the Emergency Department: a Randomized Trial
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Comparative effectiveness and safety of traditional Chinese medicine supporting Qi and enriching blood for cancer related anemia in patients not receiving chemoradiotherapy: a meta-analysis and systematic review.Drug design, development and therapy · 2019Pooled it
- Utilization of Intravenous Iron Therapy and Red Blood Cell Transfusion in Emergency Department Patients with Anemia: A Single-Center Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Exploration of patient blood management metrics for emergency departments: a 4-year retrospective monocenter study.BMC emergency medicine · 2025Article
- Article
- Implementing first pillar of PBM in the Emergency Area: a missed opportunity?Blood transfusion = Trasfusione del sangue · 2025Article
- Appropriateness of packed red blood cells transfusions in chronic anemic patients in the emergency department: the TRANSFUS-ED retrospective analysis.Internal and emergency medicine · 2023Article
- A synchronized approach between emergency department and anemia clinic to intravenous iron treatment for very severe (Hb <7.0 g/dL) and extreme (<5.0 g/dL) iron-deficiency anemia: short-, medium- and long-term efficacy and safety analysis.Blood transfusion = Trasfusione del sangue · 2023Article
- The impact of timing of intravenous iron supplementation on preoperative haemoglobin in patients scheduled for major surgery.Blood transfusion = Trasfusione del sangue · 2022Article
- Sparing unnecessary transfusions through patient blood management: time for application also in internal and emergency medicine.Internal and emergency medicine · 2020Article
- Treatment with ferric carboxymaltose in stable patients with severe iron deficiency anemia in the emergency department.Internal and emergency medicine · 2020Article
- Early intravenous iron administration in the Emergency Department reduces red blood cell unit transfusion, hospitalisation, re-transfusion, length of stay and costs.Blood transfusion = Trasfusione del sangue · 2020Article
- Iron in the General Population and Specificities in Older Adults: Metabolism, Causes and Consequences of Decrease or Overload, and Biological Assessment.Clinical interventions in aging · 2020Review
- Evidence-Based Minireview: The role of IV iron in management of patients with iron-deficiency anemia presenting to the emergency department.Hematology. American Society of Hematology. Education Program · 2019Review
- Review
- Current misconceptions in diagnosis and management of iron deficiency.Blood transfusion = Trasfusione del sangue · 2017Review
- A fast-track anaemia clinic in the Emergency Department: cost-analysis of intravenous iron administration for treating iron-deficiency anaemia.Blood transfusion = Trasfusione del sangue · 2017Article
- Appropriate use of red blood cell transfusion in emergency departments: a study in five emergency departments.Blood transfusion = Trasfusione del sangue · 2017Article
- Iron-deficiency anaemia in the Emergency Room: a new opportunity for the use of intravenous iron.Blood transfusion = Trasfusione del sangue · 2016Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinically significant anaemia, requiring red blood cell transfusions, is frequently observed in Emergency Departments (ED). To optimise blood product use, we developed a clinical protocol for the management of iron-deficiency anaemia in a fast-track anaemia clinic within the ED. MATERIALS AND
methodsFrom November 2010 to January 2014, patients presenting with sub-acute, moderate-to-severe anaemia (haemoglobin [Hb] <11 g/dL) and confirmed or suspected iron deficiency were referred to the fast-track anaemia clinic. Those with absolute or functional iron deficiency were given intravenous (IV) ferric carboxymaltose 500-1,000 mg/week and were reassessed 4 weeks after receiving the total iron dose. The primary study outcome was the haematological response (Hb≥12 g/dL and/or Hb increment ≥2 g/dL). Changes in blood and iron parameters, transfusion rates and IV iron-related adverse drug effects were secondary outcomes.
resultsTwo hundred and two anaemic patients with iron deficiency (150 women/52 men; mean age, 64 years) were managed in the fast-track anaemia clinic, and received a median IV iron dose of 1,500 mg (1,000-2,000 mg). Gastro-intestinal (44%) or gynaecological (26%) bleeding was the most frequent cause of the anaemia. At follow-up (183 patients), the mean Hb increment was 3.9±2.2 g/dL; 84% of patients were classified as responders and blood and iron parameters normalised in 90%. During follow-up, 35 (17%) patients needed transfusions (2 [range: 1-3] units per patient) because they had low Hb levels, symptoms of anaemia and/or were at risk. Eight mild and one moderate, self-limited adverse drug effects were witnessed. DISCUSSION: Our data support the feasibility of a clinical protocol for management of sub-acute anaemia with IV iron in the ED. IV iron was efficacious, safe and well tolerated. Early management of anaemia will improve the use of blood products in the ED.
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