ReviewGastrointestinal tumors2014
Chronic Pancreatitis and Pancreatic Cancer.
Review in Gastrointestinal tumors, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Endoscopic Ultrasound Guided Fine-Needle Aspiration for Solid Lesions in Chronic Pancreatitis: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2022Pooled it
- A scoring model for preoperative differentiation of high-enhancement pancreatic ductal adenocarcinoma from mass-forming chronic pancreatitis.BMC medical imaging · 2025Article
- Stromal Cells in Early Inflammation-Related Pancreatic Carcinogenesis-Biology and Its Potential Role in Therapeutic Targeting.Cancers · 2025Review
- Prediction of 12-month recurrence of pancreatic cancer using machine learning and prognostic factors.BMC medical informatics and decision making · 2024Article
- Pancreatic Cancer: A Review of Risk Factors.Life (Basel, Switzerland) · 2024Review
- Lipopolysaccharide (LPS) stimulation of Pancreatic Ductal Adenocarcinoma (PDAC) and macrophages activates the NLRP3 inflammasome that influences the levels of pro-inflammatory cytokines in a co-culture model.Cancer biology & therapy · 2023Article
- Pancreatic tail cancer in the setting of pancreatitis with a review of the literature: A case report.Clinical case reports · 2023Article
- A case of pancreatic ductal adenocarcinoma concomitant with IgG4-related disease in the pancreas and the stomach.Clinical journal of gastroenterology · 2023Article
- Modifiable and Non-Modifiable Risk Factors for the Development of Non-Hereditary Pancreatic Cancer.Medicina (Kaunas, Lithuania) · 2022Review
- Proteome Analysis of Pancreatic Tumors Implicates Extracellular Matrix in Patient Outcome.Cancer research communications · 2022Article
- Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma: A Physiopathologic and Pharmacologic Review.Cancers · 2022Review
- The Relationship between Acute and Chronic Pancreatitis with Pancreatic Adenocarcinoma: Review.Diseases (Basel, Switzerland) · 2021Review
- Could the burden of pancreatic cancer originate in childhood?World journal of gastroenterology · 2021Review
- Pancreatitis and pancreatic cancer: A case of the chicken or the egg.World journal of gastroenterology · 2021Review
- The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer.Journal of experimental & clinical cancer research : CR · 2021Article
- The Potential Therapeutic Role of Exosomal MicroRNA-520b Derived from Normal Fibroblasts in Pancreatic Cancer.Molecular therapy. Nucleic acids · 2020Article
- Lipocalin-2 expression and function in pancreatic diseases.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2020Review
- Risk of pancreatic cancer in patients undergoing surgery for chronic pancreatitis.BMC surgery · 2019Article
- Adipocyte and lipid metabolism in cancer drug resistance.The Journal of clinical investigation · 2019Review
- Mesenchymal Stem Cells as New Therapeutic Approach for Diabetes and Pancreatic Disorders.International journal of molecular sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPancreatic cancer (PC) is one of the most lethal diseases with an incidence rate almost equal to the rate of mortality. Chronic pancreatitis (CP) is a common chronic inflammatory disease of unknown etiology that affects the pancreas. Epidemiological studies have identified CP to be a major risk factor for PC. SUMMARY: A greater understanding of the molecular mechanisms linking CP and PC has identified several common pathways that provide targets for future interventions. This article reviews those components in the CP-PC connection, including the role of macrophages, the maintenance of genome stability, cytokines, and other nodal factors such as nuclear factor kappa B, COX-2 and reactive oxygen species. KEY MESSAGE: The molecular mechanisms that underlie CP and PC provide novel targets for future therapies for PC. PRACTICAL IMPLICATIONS: The stromal-desmoplastic reaction plays an important role in initiating and sustaining chronic inflammation and tumor progression. Recently, two targeted anti-tumor agents, erlotinib and nab-paclitaxel, have shown promising therapeutic efficacy. Notably, both these agents target components (EGFR and SPARC) within the inflammatory stroma surrounding malignant cells, underscoring the importance of inflammation in pancreatic carcinogenesis. Identifying the common pathways linking CP and PC may help uncover additional novel targets for future therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.