ArticleJournal of clinical and diagnostic research : JCDR2015
Prediction of Preeclampsia by First Trimester Combined Test and Simple Complete Blood Count Parameters.
Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Association between the neutrophil-to-lymphocyte ratio and preeclampsia: a systematic review and meta-analysis of observational studies.Frontiers in public health · 2026Pooled it
- A meta-analysis on first-trimester blood count parameters-is the neutrophil-to-lymphocyte ratio a potentially novel method for first-trimester preeclampsia screening?Frontiers in medicine · 2024Pooled it
- Diagnostic value of neutrophil-lymphocyte ratio in preeclampsia: A PRISMA-compliant systematic review and meta-analysis.Medicine · 2019Pooled it
- The predictive value of early-pregnancy mean platelet volume for preeclampsia: A meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2026Review
- Serum Pancreatic Stone Protein Across the Spectrum of Hypertensive Disorders of Pregnancy: Discrimination of Preeclampsia Compared with Conventional Inflammatory Indices.Medicina (Kaunas, Lithuania) · 2026Article
- The role of inflammatory indices for the prediction of preeclampsia in the first trimester: a case-control study from a tertiary center.Revista da Associacao Medica Brasileira (1992) · 2025Article
- Hematological and biochemical alterations in preeclampsia: Readings from cord blood analysis.PloS one · 2025Article
- Article
- Blood Plasma Calorimetric Profiles of Women with Preeclampsia: Effect of Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Article
- Impact of elevated first and second trimester white blood cells on prevalence of late-onset preeclampsia.Heliyon · 2022Article
- Haematological changes from conception to childbirth: An indicator of major pregnancy complications.European journal of haematology · 2022Article
- Factors Associated with the Severity of Pregnancy-Related Hypertensive Disorder: Significance of Clinical, Laboratory, and Histopathological Features.Diagnostics (Basel, Switzerland) · 2022Article
- The value of eosinophil count in the diagnosis of preeclampsia among pregnant women attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2021.BMC pregnancy and childbirth · 2022Article
- Detecting Preeclampsia Severity Using Maternal-Obstetrical Characteristics and Complete Blood Cell Counts.International journal of general medicine · 2022Article
- Neutrophil-Lymphocyte Ratio as a Screening Test for Preeclampsia in the First and Early-Third Trimesters of Pregnancy: A Cohort Study : Neutrophil-Lymphocyte Ratio and Preeclampsia.Galen medical journal · 2022Article
- An exploratory study of white blood cell proportions across preeclamptic and normotensive pregnancy by self-identified race in individuals with overweight or obesity.Hypertension in pregnancy · 2021Article
- First Trimester Mean Platelet Volume, Neutrophil to Lymphocyte Ratio, and Platelet to Lymphocyte Ratio Values Are Useful Markers for Predicting Preeclampsia.Ochsner journal · 2021Article
- First trimester complete blood cell indices in early and late onset preeclampsia.Turkish journal of obstetrics and gynecology · 2019Article
- Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio and Complete Blood Count Components in the First Trimester Do Not Predict HELLP Syndrome.Medicina (Kaunas, Lithuania) · 2019Article
- [Maternal neutrophil-to-lymphocyte ratio as a prognostic biomarker for placental inflammatory response in late pregnancy].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPreeclampsia is a serious disease which may result in maternal and neonatal mortality and morbidity. Improving the outcome for preeclampsia necessitates early prediction of the disease to identify women at high risk. Measuring blood cell subtype ratios, such as the neutrophil to lymphocyte (NLR) and platelet to lymphocyte (PLR) ratios, might provide prognostic and diagnostic clues to diseases.
aimTo investigate hematological changes in early pregnancy, using simple complete blood count (CBC) and blood concentrations of beta-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein-A (PAPP-A) to determine whether these measures are of any value in the prediction and early diagnosis of preeclampsia. MATERIALS AND
methodsSix hundred fourteen consecutive pregnant women with preeclampsia (288 with mild disease and 326 with severe disease) and 320 uncomplicated pregnant women were included in the study. Blood samples for routine CBC and first trimester screen, which combines PAPP-A and free β-hCG blood concentrations, were analyzed.
resultsThe NLR values were significantly higher in the severe preeclampsia group compared with the control group (p<0.001). We also confirmed that levels of PAPP-A were lower in patients who developed preeclampsia.
conclusionBecause measuring CBC parameters, particularly NLR, is fast and easily applicable, they may be used to predict preeclampsia.
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