ReviewOrthopaedic journal of sports medicine2015
The Effect of Intra-articular Corticosteroids on Articular Cartilage: A Systematic Review.
Review in Orthopaedic journal of sports medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05806021 (The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis), which is not on this map. Cited by 161 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Efficacy of Intra-articular Triamcinolone Acetonide 5mg vs. 10 mg vs. 40 mg in Patients With Knee Osteoarthritis: a Non-inferiority Randomized Controlled Double-blind Study
Who cites it
161 citing papers in PubMed, 8 syntheses or guidelines pooled it, 345 citations in OpenAlex.
- Ozone injections reduce pain in knee osteoarthritis: a systematic review and meta-analysis.Medical gas research · 2026Pooled it
- Intra-articular corticosteroid Injection combined with physical therapy versus physical therapy alone for adhesive capsulitis: a meta-analysis of randomized controlled trials.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Pooled it
- Consensus practice guidelines on sacroiliac joint complex pain from a multispecialty, international working group.Pain medicine (Malden, Mass.) · 2025Guideline
- Pain management of hip osteoarthritis with corticosteroids vs injection therapies: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2025Pooled it
- Long-term effectiveness of intra-articular injectables in patients with knee osteoarthritis: a systematic review and Bayesian network meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Avascular necrosis or rapid destruction of the hip following hip intra-articular corticosteroid injections: a systematic review.International orthopaedics · 2025Pooled it
- The EANM guideline for radiosynoviorthesis.European journal of nuclear medicine and molecular imaging · 2022Guideline
- Intra-articular injection of methylprednisolone for reducing pain in knee osteoarthritis: A systematic review and meta-analysis.Medicine · 2018Pooled it
- Efficacy and safety of a combination of platelet-rich plasma with non-crosslinked hyaluronic acid versus a crosslinked hyaluronic acid, in single-injection for knee osteoarthritis. Randomized, controlled, multicenter, non-inferiority trial.BMC musculoskeletal disorders · 2026Trial
- Genicular nerve block in juvenile idiopathic arthritis: a randomized clinical trial.Clinical rheumatology · 2023Trial
- The efficacy of intra-articular triamcinolone acetonide 10 mg vs. 40 mg in patients with knee osteoarthritis: a non-inferiority, randomized, controlled, double-blind, multicenter study.BMC musculoskeletal disorders · 2023Trial
- Outcomes of ketorolac versus depomedrol infiltrations for subacromial impingement syndrome: a randomized controlled trial.Musculoskeletal surgery · 2022Trial
- Intra-articular platelet-rich plasma vs corticosteroids in the treatment of moderate knee osteoarthritis: a single-center prospective randomized controlled study with a 1-year follow up.Journal of orthopaedic surgery and research · 2020Trial
- Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial.Annals of family medicine · 2020Trial
- A randomized, controlled study to evaluate the efficacy of intra-articular, autologous adipose tissue injections for the treatment of mild-to-moderate knee osteoarthritis compared to hyaluronic acid: a study protocol.BMC musculoskeletal disorders · 2018Trial
- Trial
- Updates in ultrasound-guided musculoskeletal interventions.The British journal of radiology · 2026Review
- From Physicochemical Properties to Rehabilitation Outcomes: Understanding Corticosteroid Injection Adverse Effects.International journal of molecular sciences · 2026Review
- Efficacy of Oxygen-Ozone Therapy for Shoulder Disorders: A Systematic Review of Randomized Controlled Trials.Journal of clinical medicine · 2026Review
- In Vitro Cytotoxicity and Inflammatory Response of Local Anaesthetics and Corticosteroids in Canine Fibroblast-Like Synoviocytes.Cartilage · 2026Article
101 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntra-articular (IA) corticosteroid therapy has been used for the treatment of inflammation and pain in the knee since the 1950s. PURPOSE: To review the current literature on the effects of IA corticosteroids on articular cartilage. STUDY
designSystematic review.
methodsA MEDLINE and SCOPUS database search was performed, and studies were selected for basic science and clinical trial research on corticosteroids with direct outcome measures of cartilage health. Preliminary searches yielded 1929 articles, and final analysis includes 40 studies.
resultsMethylprednisolone, dexamethasone, hydrocortisone, betamethasone, prednisolone, and triamcinolone were reported to display dose-dependent deleterious effects on cartilage morphology, histology, and viability in both in vitro and in vivo models. The beneficial animal in vivo effects of methylprednisolone, hydrocortisone, and triamcinolone occurred at low doses (usually <2-3 mg/dose or 8-12 mg/cumulative total dose in vivo), at which increased cell growth and recovery from damage was observed; the single human clinical trial indicated a beneficial effect of triamcinolone. However, at higher doses (>3 mg/dose or 18-24 mg/cumulative total dose in vivo), corticosteroids were associated with significant gross cartilage damage and chondrocyte toxicity. Dose and time dependency of corticosteroid chondrotoxicity was supported in the in vitro results, however, without clear dose thresholds.
conclusionCorticosteroids have a time- and dose-dependent effect on articular cartilage, with beneficial effects occurring at low doses and durations and detrimental effects at high doses and durations. Clinically, beneficial effects are supported for IA administration, but the lowest efficacious dose should be used.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.