Evidence map›Paper›PMID 26674550›Full record

ReviewPhysiology (Bethesda, Md.)2016

Pulsatility of Hypothalamo-Pituitary Hormones: A Challenge in Quantification.

Daniel M Keenan, Johannes D Veldhuis

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Quantitative approaches in clinical reproductive endocrinology.Current opinion in endocrine and metabolic research · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Dynamic Pituitary-Adrenal Interactions in the Critically Ill after Cardiac Surgery.The Journal of clinical endocrinology and metabolism · 2020
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Daniel M KeenanDepartment of Statistics, University of Virginia, Charlottesville, Virginia; and.
Johannes D VeldhuisDepartment of Medicine, Endocrine Research Unit, Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota veldhuis.johannes@mayo.edu.

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Age-Dependent Estrogen-Independent Mechanism of Hyposomatotropism in WomenR01AG029362 · NIA · MAYO CLINIC ROCHESTER · PI VELDHUIS, JOHANNES D · 2007 to 2016
$4.0M
Aging Systems in Geriatrics: the Male Gonadal AxisR01AG031763 · NIA · MAYO CLINIC ROCHESTER · PI VELDHUIS, JOHANNES D · 2010 to 2014
$1.9M
Actions of Testosterone on the Aging Male GH AxisR01AG019695 · NIA · MAYO CLINIC ROCHESTER · PI VELDHUIS, JOHANNES D · 2012 to 2016
$1.9M
Ensemble Control of ACTH Secretion: Impact of GenderR01DK073148 · NIDDK · MAYO CLINIC ROCHESTER · PI VELDHUIS, JOHANNES D · 2007 to 2011
$1.4M
NCATS NIH HHS UL1 TR000135NIA NIH HHS R01 AG-019695NIA NIH HHS R01 AG019695NIA NIH HHS R01 AG-029362NIA NIH HHS R01 AG029362NIA NIH HHS R01 AG-031763NIA NIH HHS R01 AG031763NIDDK NIH HHS R01 DK-073148NIDDK NIH HHS R01 DK073148
6 · The paper itself

Abstract

Neuroendocrine systems control many of the most fundamental physiological processes, e.g., reproduction, growth, adaptations to stress, and metabolism. Each such system involves the hypothalamus, the pituitary, and a specific target gland or organ. In the quantification of the interactions among these components, biostatistical modeling has played an important role. In the present article, five key challenges to an understanding of the interactions of these systems are illustrated and discussed critically.

Indexed as

HumansHypothalamo-Hypophyseal SystemHypothalamusPituitary GlandPituitary HormonesPituitary Hormones

Identifiers

PMID26674550
PMCPMC4698454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.