Trial reportBMJ open2015
VITALITY trial: protocol for a randomised controlled trial to establish the role of postnatal vitamin D supplementation in infant immune health.
Trial report in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02112734 (Can Vitamin D Supplementation Prevent Food Allergy in Infants? The VITALITY Trial), which is not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Can Vitamin D Supplementation Prevent Food Allergy in Infants? The VITALITY Trial
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Vitamin D supplementation in pregnant or breastfeeding women or young children for preventing asthma.The Cochrane database of systematic reviews · 2025Pooled it
- Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health.The Cochrane database of systematic reviews · 2020Pooled it
- Effects of oral vitamin D supplementation on linear growth and other health outcomes among children under five years of age.The Cochrane database of systematic reviews · 2020Pooled it
- VITALITY - a longitudinal cohort established to assess the role of postnatal vitamin D supplementation in atopic disease and immune health.European journal of epidemiology · 2026Article
- Shotgun Metagenomics Reveals Skin Microbiome Composition and Function in Infant Atopic Disease.Allergy · 2026Article
- Vitamin D Supplementation and Serum 25-Hydroxyvitamin D Response in Infants and Children: A Narrative Review.Pediatric health, medicine and therapeutics · 2026Review
- Prevention of IgE-Mediated Food Allergy: Emerging Strategies Through Maternal and Neonatal Interventions.The journal of allergy and clinical immunology. In practice · 2024Review
- Environmental Interventions for Preventing Atopic Diseases.Current allergy and asthma reports · 2024Review
- A genome catalog of the early-life human skin microbiome.Genome biology · 2023Article
- A genome catalog of the early-life human skin microbiome.bioRxiv : the preprint server for biology · 2023Article
- Advances and potential of omics studies for understanding the development of food allergy.Frontiers in allergy · 2023Review
- Data Resource Profile: Melbourne Children's LifeCourse initiative (LifeCourse).International journal of epidemiology · 2022Article
- Fat-soluble vitamins: updated review of their role and orchestration in human nutrition throughout life cycle with sex differences.Nutrition & metabolism · 2022Review
- Article
- An Overview of Environmental Risk Factors for Food Allergy.International journal of environmental research and public health · 2022Review
- Nutritional management of food allergies: Prevention and treatment.Frontiers in allergy · 2022Review
- Real-World LEAP Implementation.Current allergy and asthma reports · 2021Review
- Allergy Prevention: An Overview of Current Evidence.The Yale journal of biology and medicine · 2020Review
- Vitamin D and Immunity in Infants and Children.Nutrients · 2020Review
- Factors Affecting Vitamin D Status in Infants.Children (Basel, Switzerland) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPostnatal vitamin D supplementation may be associated with a reduction in IgE-mediated food allergy, lower respiratory tract infections and improved bone health. Countries in the Northern hemisphere recommend universal infant vitamin D supplementation to optimise early vitamin D levels, despite the absence of large trials proving safety or efficacy for any disease outcome. With the aim of determining the clinical and cost-effectiveness of daily vitamin D supplementation in breastfed infants from age 6-8 weeks to 12 months of age, we have started a double-blind, randomised, placebo-controlled trial of daily 400 IU vitamin D supplementation during the first year of life, VITALITY. METHODS ND ANALYSIS: Infants (n=3012) who are fully breastfed and not receiving vitamin D supplementation will be recruited at the time of their first immunisation, from council-led immunisation clinics throughout metropolitan Melbourne, Australia. The primary outcome is challenge-proven food allergy at 12 months of age. Secondary outcomes are food sensitisation (positive skin prick test), number of lower respiratory infections (through hospital linkage), moderately-severe and persistent eczema (by history and examination) and vitamin D deficiency (serum vitamin D <50 nmol/L) at age 12 months. The trial is underway and the first 130 participants have been recruited. ETHICS AND DISSEMINATION: The VITALITY study is approved by the Royal Children's Hospital (RCH) Human Research Ethics Committee (#34168). Outcomes will be disseminated through publication and will be presented at scientific conferences. TRIAL REGISTRATION NUMBERS: ANZCTR12614000334606 and NCT02112734; pre-results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.