ArticlePLoS biology2015
Drosophila Avoids Parasitoids by Sensing Their Semiochemicals via a Dedicated Olfactory Circuit.
Article in PLoS biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
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Who cites it
92 citing papers in PubMed, 215 citations in OpenAlex.
- Article
- A predator-derived odor specifically triggers avoidance in gregarious mated female Locusta migratoria.Pest management science · 2026Article
- Non-consumptive effects of Harmonia axyridis (Coleoptera: Coccinellidae) derived semiochemicals on Myzus persicae (Hemiptera: Aphididae).Journal of insect science (Online) · 2026Article
- Multisensory pathogen detection drives rapid escape and shapes host-microbe interactions in Drosophila larvae.PLoS pathogens · 2026Article
- A roadmap to key traits of invasive Drosophilidae.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Advances and Prospects in Odour-based Management of Filth Flies.Journal of chemical ecology · 2026Review
- Gustatory sensing by ovipositor drives maternal avoidance of hesperidin to benefit the offspring in a major agricultural fly pest.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Neurotransmitter signaling in molecular and behavioral immune responses to pathogens inMicrobiology and molecular biology reviews : MMBR · 2025Review
- Ants' semiochemicals deters Philaenus spumarius (Hemiptera: Aphrophoridae) activity on olive trees.Journal of economic entomology · 2025Article
- Multifaceted Defenses Against Parasitoid Wasps in Diptera.Annual review of genetics · 2025Review
- Article
- When noncanonical olfaction is optimal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Flies use acetic acid to protect their offspring from parasitoids.PLoS pathogens · 2025Article
- Loss of olfaction reduces caterpillar performance and increases susceptibility to a natural enemy.eLife · 2025Article
- New dimensions in the molecular genetics of insect chemoreception.Trends in genetics : TIG · 2025Review
- Embryogenesis in Myrmicine Ants Combines Features of Short Germ-Band Development With a Progressive Mode of Segmentation.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Article
- Evolutionary Process Underlying Receptor Gene Expansion and Cellular Divergence of Olfactory Sensory Neurons in Honeybees.Molecular biology and evolution · 2025Article
- Recalibrating Olfactory Neuroscience to the Range of Naturally Occurring Odor Concentrations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Microbiome-emitted scents activate olfactory neuron-independent airway-gut-brain axis to promote host growth in Drosophila.Nature communications · 2025Article
32 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detecting danger is one of the foremost tasks for a neural system. Larval parasitoids constitute clear danger to Drosophila, as up to 80% of fly larvae become parasitized in nature. We show that Drosophila melanogaster larvae and adults avoid sites smelling of the main parasitoid enemies, Leptopilina wasps. This avoidance is mediated via a highly specific olfactory sensory neuron (OSN) type. While the larval OSN expresses the olfactory receptor Or49a and is tuned to the Leptopilina odor iridomyrmecin, the adult expresses both Or49a and Or85f and in addition detects the wasp odors actinidine and nepetalactol. The information is transferred via projection neurons to a specific part of the lateral horn known to be involved in mediating avoidance. Drosophila has thus developed a dedicated circuit to detect a life-threatening enemy based on the smell of its semiochemicals. Such an enemy-detecting olfactory circuit has earlier only been characterized in mice and nematodes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.