Evidence map›Paper›PMID 26674303›Full record

ReviewJournal of clinical and diagnostic research : JCDR2015

Acute Phase Proteins and Their Role in Periodontitis: A Review.

Tejaswin Polepalle, Srinivas Moogala, Shalini Boggarapu, Divya Sai Pesala, Firoz Babu Palagi

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. More than just teeth: How oral health can affect the heart.American heart journal plus : cardiology research and practice · 2024
    Review
  10. Review
  11. Review
  12. Mechanism and application ofFrontiers in public health · 2023
    Review
  13. Article
  14. Inflammation: A New Look at an Old Problem.International journal of molecular sciences · 2022
    Review
  15. Article
  16. Article
  17. [Research progress of correlation between periodontal pathogens and systemic diseases].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020
    Review
  18. Review
  19. [Anemia in the aged].Zeitschrift fur Gerontologie und Geriatrie · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tejaswin PolepalleSenior Lecturer, Department of Periodontics, SIBAR Institute of Dental Sciences , Guntur, India .
Srinivas MoogalaProfessor, Department of Periodontics, SIBAR Institute of Dental Sciences , Guntur, India .
Shalini BoggarapuPost Graduate Student, Department of Periodontics, SIBAR Institute of Dental Sciences , Guntur, India .
Divya Sai PesalaPost Graduate Student, Department of Pathology, Siddhartha Medical College , Vijayawada, India .
Firoz Babu PalagiSenior Lecturer, Department of Orthodontics and Dentofacial Orthopaedics, Rama Dental College , Kanpur, India .
Kamineni Institute of Dental Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute phase proteins are a class of proteins whose plasma concentration increase (positive acute phase proteins) or decrease (negative acute phase proteins) in response to inflammation. This response is called as the acute phase reaction, also called as acute phase response, which occurs approximately 90 minutes after the onset of a systemic inflammatory reaction. In Periodontitis endotoxins released from gram negative organisms present in the sub gingival plaque samples interact with Toll- like receptors (TLR) that are expressed on the surface of Polymorphonuclear leucocytes (PMNs) and monocytes which are in abundance in periodontal inflammation. The complex formed due to interaction of Endotoxins and TLR activates the Signal transduction pathway in both innate and adaptive immunity resulting in production of Cytokines that co- ordinate the local and systemic inflammatory response. The pro inflammatory cytokines originating at the diseased site activates the liver cells to produce acute phase proteins as a part of non specific response. The production of Acute phase proteins is regulated to a great extent by Cytokines such as IL-1, IL-6, IL-8, TNF-α and to a lesser extent by Glucocorticoid hormones. These proteins bind to bacteria leading to activation of complement proteins that destroys pathogenic organisms. Studies have shown that levels of acute phase proteins are increased in otherwise healthy adults with poor periodontal status. This article highlights about the synthesis, structure, types and function of acute phase proteins and the associated relation of acute phase proteins in Periodontitis.

Indexed as

Acute phase proteinsCytokinesInflammation

Identifiers

PMID26674303
PMCPMC4668538
OpenAlexW2415044240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.