Evidence map›Paper›PMID 26674259›Full record

ReviewDose-response : a publication of International Hormesis Society

Why Does Exercise "Trigger" Adaptive Protective Responses in the Heart?

Rick J Alleman, Luke M Stewart, Alvin M Tsang, David A Brown

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Exercise: Teaching myocytes new tricks.Journal of applied physiology (Bethesda, Md. : 1985) · 2017
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rick J AllemanDepartment of Physiology and East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville NC USA.
Luke M StewartDepartment of Physiology and East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville NC USA.
Alvin M TsangDepartment of Physiology and East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville NC USA.
David A BrownDepartment of Physiology and East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville NC USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous epidemiological studies suggest that individuals who exercise have decreased cardiac morbidity and mortality. Pre-clinical studies in animal models also find clear cardioprotective phenotypes in animals that exercise, specifically characterized by lower myocardial infarction and arrhythmia. Despite the clear benefits, the underlying cellular and molecular mechanisms that are responsible for exercise preconditioning are not fully understood. In particular, the adaptive signaling events that occur during exercise to "trigger" cardioprotection represent emerging paradigms. In this review, we discuss recent studies that have identified several different factors that appear to initiate exercise preconditioning. We summarize the evidence for and against specific cellular factors in triggering exercise adaptations and identify areas for future study.

Indexed as

cardiacexerciseheartmitochondriaPreconditioning

Identifiers

PMID26674259
PMCPMC4674163

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.