Evidence map›Paper›PMID 26674249›Full record

ArticleJournal of clinical and diagnostic research : JCDR2015

Detection and Quantification of Free Radicals in Peroxisomal Disorders: A Comparative Study with Oxidative Stress Parameters.

Sohair Abd-El Mawgood Abd-Elmaksoud, Hala El-Bassyouni, Hanan Afifi, Manal Micheal Thomas, Alshaymaa Ahmed Ibrahim, Aliaa Shalaby, Tamer Ahmed Abdel Hamid, Nehal Abdel Hamid, Hany El-Ghobary

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Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sohair Abd-El Mawgood Abd-ElmaksoudProfessor, Department of Clinical Pathology, National Research Centre , Egypt .
Hala El-BassyouniProfessor, Department of Clinical Genetics, National Research Centre , Egypt .
Hanan AfifiProfessor, Department of Clinical Genetics, National Research Centre , Egypt .
Manal Micheal ThomasResearcher, Department of Clinical Genetics, National Research Centre , Egypt .
Alshaymaa Ahmed IbrahimResearcher, Department of Clinical Pathology, National Research Centre , Egypt .
Aliaa ShalabyResearcher, Department of Clinical Pathology, National Research Centre , Egypt .
Tamer Ahmed Abdel HamidLecturer, Department of Paediatric, Faculty of Medicine, Cairo University , Egypt .
Nehal Abdel HamidResearcher, Department of Paediatric, National Research Centre , Egypt .
Hany El-GhobaryLecturer, Department of Clinical and Chemical Pathology, Faculty of Medicine, Cairo University , Egypt .
National Research Centre · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFree radicals have been thought to participate in pathogenesis of peroxisomal disorders.

objectiveThe aim of the work is to detect free oxide radicals in blood of patients with peroxisomal disorders and to study their relation with various oxidative stress parameters. MATERIALS AND

methodsTwenty patients with peroxisomal disorders and 14 age and sex matched healthy subjects were included in the study. Patients with peroxisomal disorders were subdivided according to diagnosis into peroxisomal biogenesis disorders and single enzyme deficiency. Oxidative stress was evaluated in both patients and control subjects by assessment of free radicals, malondialdehyde, nitric oxide metabolites and superoxide dismutase.

resultsThere was increase in free radicals, malondialdehyde, nitric oxide metabolites in patients compared with control subjects. However, there was decrease in superoxide dismutase levels in patients compared with control subjects.

conclusionWe concluded that there is excess free radicals production accompanied with decrease in antioxidant defenses in patients with peroxisomal disorders. These results strongly support a role of free radicals in the pathophysiology of peroxisomal disorders and strengthen the importance of oxidative stress phenomenon in peroxisomal disorders pathogenesis.

Indexed as

MalondialdehydeNitric oxideSuperoxide dismutase

Identifiers

PMID26674249
PMCPMC4668497
OpenAlexW2403656591

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