ArticleJournal of clinical and diagnostic research : JCDR2015
Study on Subclinical Hypothyroidism and its Association with Various Inflammatory Markers.
Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Article
- Chronic inflammatory activity in women with normogonadotropic anovulation complicated by subclinical thyroid dysfunction: a prospective cohort study.Frontiers in endocrinology · 2026Article
- Prevalence of Subclinical Hypothyroidism in Information Technology Professionals With High Screen Exposure.Cureus · 2025Article
- Plasma Alzheimer's disease biomarker variability: Amyloid-independent and amyloid-dependent factors.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Evaluation of the hematological parameters, inflammatory biomarkers, and thyroid hormones in hypothyroidism patients.BMC research notes · 2024Article
- Association of Thyroid Dysfunction in Individuals ≥ 65 Years of Age With Subclinical Cardiac Abnormalities.The Journal of clinical endocrinology and metabolism · 2024Article
- Subclinical hypothyroidism predicts outcome in heart failure: insights from the T.O.S.CA. registry.Internal and emergency medicine · 2024Observational
- Eltroxin and Hesperidin mitigate testicular and renal damage in hypothyroid rats: amelioration of oxidative stress through PPARγ and Nrf2/HO-1 signaling pathway.Laboratory animal research · 2024Article
- Associations between empirically derived dietary patterns and oxidative stress and inflammation in adults with primary hypothyroidism: a case-control study.BMC endocrine disorders · 2023Article
- Lumbar spine intervertebral disc desiccation is associated with medical comorbidities linked to systemic inflammation.Archives of orthopaedic and trauma surgery · 2023Article
- The causal relationship between 41 inflammatory cytokines and hypothyroidism: bidirectional two-sample Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Causal Association of Thyroid Signaling with C-Reactive Protein: A Bidirectional Mendelian Randomization.Computational and mathematical methods in medicine · 2022Article
- Identifying Non-Linear Association Between Maternal Free Thyroxine and Risk of Preterm Delivery by a Machine Learning Model.Frontiers in endocrinology · 2022Article
- Inflammasome activation as a link between obesity and thyroid disorders: Implications for an integrated clinical management.Frontiers in endocrinology · 2022Review
- Obesity and Thyroid Axis.International journal of environmental research and public health · 2021Review
- Prevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy.International journal of general medicine · 2021Article
- [The thyroid gland in old age : Physiology and pathology].Wiener medizinische Wochenschrift (1946) · 2020Article
- Reduction in Thyroid-Stimulating Hormone Correlated with Improved Inflammation Markers in Chinese Patients with Morbid Obesity Undergoing Laparoscopic Sleeve Gastrectomy.Obesity surgery · 2019Article
- Predictors of Atrial Fibrillation in Patients With Cryptogenic Stroke.The Neurohospitalist · 2019Article
- Subclinical hypothyroidism and the development of heart failure: an overview of risk and effects on cardiac function.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSubclinical hypothyroidism shows the mimic reaction more like to frank hypothyroidism which creates the dilemma. Inflammatory markers can be helpful in assessment of adverse effects of subclinical hypothyroidism, are not very well studied in the past. So the aim of this study was to investigate the role of inflammatory markers in Subclinical hypothyroidism patients. MATERIALS AND
methodsThe study population consisted of 154 patients with recently diagnosed subclinical hypothyroidism and 100 healthy controls. TSH, FT4 & T3 were estimated by enzyme linked Immunosorbent assay (ELISA) for diagnosis of subclinical hypothyroidism. Total cholesterol, triglycerides, and HDL-C were estimated by spectrophotometric method. LDL - C was calculated by Friedewald formula. Inflammatory markers (ESR, C-reactive protein & Interleukin 6) were also estimated by enzyme linked Immunosorbent assay (ELISA).
resultsIn this study the level of TSH Mean ± SD (11.12±4.17 vs 2.73±0.80) and T3 Mean ± SD (0.96±0.17 vs 1.08±0.26) were significantly higher (<0.001) in subclinical hypothyroidism. Serum concentration of FT4 was not significantly different between the groups. Total cholesterol, triglycerides, and LDL-C were significantly higher in patients group. While the level of HDL-C was significantly lower in SCH patients compared to euthyroid group. TSH level was positively correlated with inflammatory markers in subclinical hypothyroidism, which were significantly different in subclinical hypothyroidism.
conclusionThis study suggests that subclinical hypo-thyroidism patients have increased inflammatory markers along with dyslipidemia and due to that future risk of further development of cardiovascular disorder can occur. Level of inflammatory markers increases in patients as disease progress if left untreated.
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