ArticleBiomicrofluidics2015
Isolation and enrichment of low abundant particles with insulator-based dielectrophoresis.
Article in Biomicrofluidics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Visual and Quantitative Analysis of the Trapping Volume in Dielectrophoresis of Nanoparticles.Nano letters · 2024Article
- The latest advances on nonlinear insulator-based electrokinetic microsystems under direct current and low-frequency alternating current fields: a review.Analytical and bioanalytical chemistry · 2022Review
- Methods of Generating Dielectrophoretic Force for Microfluidic Manipulation of Bioparticles.ACS biomaterials science & engineering · 2021Review
- Microscale nonlinear electrokinetics for the analysis of cellular materials in clinical applications: a review.Mikrochimica acta · 2021Review
- Determination of the Empirical Electrokinetic Equilibrium Condition of Microorganisms in Microfluidic Devices.Biosensors · 2020Article
- High-throughput dielectrophoretic filtration of sub-micron and micro particles in macroscopic porous materials.Analytical and bioanalytical chemistry · 2020Article
- Effects of surface treatments on trapping with DC insulator-based dielectrophoresis.The Analyst · 2019Article
- A mathematical model of dielectrophoretic data to connect measurements with cell properties.Analytical and bioanalytical chemistry · 2019Article
- A review of polystyrene bead manipulation by dielectrophoresis.RSC advances · 2019Review
- Dielectrophoresis-based microfluidic platforms for cancer diagnostics.Biomicrofluidics · 2018Review
- A portable system for processing donated whole blood into high quality components without centrifugation.PloS one · 2018Article
- Assessment of Sub-Micron Particles by Exploiting Charge Differences with Dielectrophoresis.Micromachines · 2017Article
- Microfluidics cell sample preparation for analysis: Advances in efficient cell enrichment and precise single cell capture.Biomicrofluidics · 2017Review
- Refinement of current monitoring methodology for electroosmotic flow assessment under low ionic strength conditions.Biomicrofluidics · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isolation and enrichment of low-abundant particles are essential steps in many bio-analytical and clinical applications. In this work, the capability of an insulator-based dielectrophoresis (iDEP) device for the detection and stable capture of low abundant polystyrene particles and yeast cells was evaluated. Binary and tertiary mixtures of particles and cells were tested, where the low-abundant particles had concentration ratios on the order of 1:10 000 000 compared to the other particles present in the mixture. The results demonstrated successful and stable capture and enrichment of rare particles and cells (trapping efficiencies over 99%), where particles remained trapped in a stable manner for up to 4 min. A device with four reservoirs was employed for the separation and enrichment of rare particles, where the particles of interest were first selectively concentrated and then effectively directed to a side port for future collection and analysis. The present study demonstrates that simple iDEP devices have appropriate screening capacity and can be used for handling samples containing rare particles; achieving both enrichment and isolation of low-abundant particles and cells.
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Registered trials
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